Individualized prediction of non-sentinel lymph node metastasis in Chinese breast cancer patients with ≥ 3 positive sentinel lymph nodes based on machine-learning algorithms.

Journal: BMC cancer
PMID: 39223574

Abstract

BACKGROUND: Axillary lymph node dissection (ALND) is a standard procedure for early-stage breast cancer (BC) patients with three or more positive sentinel lymph nodes (SLNs). However, ALND can lead to significant postoperative complications without always providing additional clinical benefits. This study aims to develop machine-learning (ML) models to predict non-sentinel lymph node (non-SLN) metastasis in Chinese BC patients with three or more positive SLNs, potentially allowing the omission of ALND.

Authors

  • Xiangli Xie
    The Breast Center, Jieyang People's Hospital, Jieyang, Guangdong, 522000, People's Republic of China.
  • Yutong Fang
    The Breast Center, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, 515041, People's Republic of China.
  • Lifang He
    Department of Healthcare Policy and Research, Weill Cornell Medical College, Cornell University, NY.
  • Zexiao Chen
    The Breast Center, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, 515041, People's Republic of China.
  • Chunfa Chen
    The Breast Center, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, 515041, People's Republic of China.
  • Huancheng Zeng
    The Breast Center, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, 515041, People's Republic of China.
  • Bingfeng Chen
    The Breast Center, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, 515041, People's Republic of China.
  • Guangsheng Huang
    The Breast Center, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, 515041, People's Republic of China.
  • Cuiping Guo
    The Breast Center, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, 515041, People's Republic of China.
  • Qunchen Zhang
    Department of Breast, Jiangmen Central Hospital, Jiangmen, Guangdong, 529030, People's Republic of China. qczhang2014@163.com.
  • Jundong Wu

Keywords

External Resources

Popular Topics
Recent Journals