Diagnostic potential of salivary microbiota in persistent pulmonary nodules: identifying biomarkers and functional pathways using 16S rRNA sequencing and machine learning.

Journal: Journal of translational medicine
PMID: 39609902

Abstract

BACKGROUND: The aim of this study was to explore the microbial variations and biomarkers in the oral environment of patients with persistent pulmonary nodules (pPNs) and to reveal the potential biological functions of the salivary microbiota in pPNs.

Authors

  • Xiao Zeng
    Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610072, Sichuan Province, China.
  • Qiong Ma
    Beijing Institute of Radiation Medicine, 27 Taiping Road, 100850, Beijing, China.
  • Chun-Xia Huang
    Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610072, Sichuan Province, China.
  • Jun-Jie Xiao
    Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610072, Sichuan Province, China.
  • Xi Fu
    Department of Oncology, Pidu District People's Hospital, Chengdu, Sichuan, China.
  • Yi-Feng Ren
    Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610072, Sichuan Province, China.
  • Yu-Li Qu
    College of Artificial Intelligence, Xi'an Jiaotong University, Xian, 710061, Shanxi Province, China.
  • Hong-Xia Xiang
    Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610072, Sichuan Province, China.
  • Mao Lei
    Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610072, Sichuan Province, China.
  • Ru-Yi Zheng
    Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610072, Sichuan Province, China.
  • Yang Zhong
    Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
  • Ping Xiao
    Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization/National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine,National Administration of Traditional Chinese Medicine Key Laboratory of Chinese Medicinal Resources Recycling Utilization, Nanjing University of Chinese Medicine Nanjing 210023, China.
  • Xiang Zhuang
    College of Computer Science and Technology, Zhejiang University, Hangzhou 310027, China.
  • Feng-Ming You
    Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610072, Sichuan Province, China. yfmdoc@163.com.
  • Jia-Wei He
    Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610072, Sichuan Province, China. damonvincent@foxmail.com.

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