SBRT and HDR brachytherapy produce lower PSA nadirs and different PSA decay patterns than conventionally fractionated IMRT in patients with low- or intermediate-risk prostate cancer.

Journal: Practical radiation oncology
Published Date:

Abstract

PURPOSE: To compare patterns of prostate-specific antigen (PSA) response following stereotactic body radiation therapy (SBRT), high-dose-rate (HDR) brachytherapy, and conventionally fractionated intensity modulated radiation therapy (IMRT) in patients with low- or intermediate-risk prostate cancer (CaP).

Authors

  • Amar U Kishan
    Department of Radiation Oncology, University of California Los Angeles, Los Angeles, California.
  • Pin-Chieh Wang
    Department of Radiation Oncology, University of California Los Angeles, Los Angeles, California.
  • Shrinivasa K Upadhyaya
    Department of Biological and Agricultural Engineering, University of California, Davis, Davis, California.
  • Henrik Hauswald
    Department of Radiation Oncology and Radiation Therapy, Heidelberg University Hospital, Heidelberg, Germany.
  • D Jeffrey Demanes
    Department of Radiation Oncology, University of California Los Angeles, Los Angeles, California.
  • Nicholas G Nickols
    Department of Radiation Oncology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California; Department of Radiation Oncology, Stanford University, Stanford, California.
  • Mitchell Kamrava
    Department of Radiation Oncology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Ahmad Sadeghi
    Department of Radiation Oncology, Veteran Affairs Greater Los Angeles Healthcare System, Los Angeles, California.
  • Patrick A Kupelian
    Department of Radiation Oncology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.
  • Michael L Steinberg
    Department of Radiation Oncology, University of California Los Angeles, Los Angeles, California.
  • Nicolas D Prionas
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California.
  • Mark K Buyyounouski
    Department of Radiation Oncology, Stanford University, Stanford, California.
  • Christopher R King
    Department of Anesthesiology, Washington University in St Louis, St Louis, MO, 63110, USA.