Non-invasive screening for laryngeal cancer using the oral cavity as a proxy for differentiation of laryngeal cancer versus leukoplakia: A novel application of ESS technology and artificial intelligence supported statistical modeling.

Journal: American journal of otolaryngology
PMID:

Abstract

OBJECTIVE: This preliminary study tested whether non-invasive, remote Elastic Scattering Spectroscopy (ESS) measurements obtained in the oral cavity can be used as a proxy to accurately differentiate between patients with laryngeal cancer versus laryngeal leukoplakia.

Authors

  • M Sakharkar
    Boston University Chobanian and Avedisian School of Medicine, 72 E. Concord Street, Boston, MA 02118, USA. Electronic address: mitalisa@bu.edu.
  • G Spokas
    Boston University Chobanian and Avedisian School of Medicine, 72 E. Concord Street, Boston, MA 02118, USA; Department of Otolaryngology, Boston Medical Center, 800 Harrison Avenue, Boston, MA 02118, USA. Electronic address: gabriele.spokas@bmc.org.
  • L Berry
    Boston University Chobanian and Avedisian School of Medicine, 72 E. Concord Street, Boston, MA 02118, USA; Department of Otolaryngology, Boston Medical Center, 800 Harrison Avenue, Boston, MA 02118, USA. Electronic address: lucas.berry@bmc.org.
  • K Daniels
    Augusta University/University of Georgia Medical Partnership, Medical College of Georgia, Athens, GA, USA. Electronic address: KADDANIELS@augusta.edu.
  • P Nithagon
    Boston University Chobanian and Avedisian School of Medicine, 72 E. Concord Street, Boston, MA 02118, USA. Electronic address: nithagon@bu.edu.
  • E Rodriguez-Diaz
    Department of Biomedical Engineering, Boston University, Boston, MA, USA. Electronic address: eladior@bu.edu.
  • L Tracy
    Boston University Chobanian and Avedisian School of Medicine, 72 E. Concord Street, Boston, MA 02118, USA; Department of Otolaryngology, Boston Medical Center, 800 Harrison Avenue, Boston, MA 02118, USA.
  • J P Noordzij
    Boston University Chobanian and Avedisian School of Medicine, 72 E. Concord Street, Boston, MA 02118, USA; Department of Otolaryngology, Boston Medical Center, 800 Harrison Avenue, Boston, MA 02118, USA.
  • I Bigio
    Department of Biomedical Engineering, Boston University, Boston, MA, USA; Department of Electrical and Computer Engineering, Boston University, Boston, MA, USA. Electronic address: bigio@bu.edu.
  • G Grillone
    Boston University Chobanian and Avedisian School of Medicine, 72 E. Concord Street, Boston, MA 02118, USA; Department of Otolaryngology, Boston Medical Center, 800 Harrison Avenue, Boston, MA 02118, USA. Electronic address: gregory.grillone@bmc.org.
  • G P Krisciunas
    Boston University Chobanian and Avedisian School of Medicine, 72 E. Concord Street, Boston, MA 02118, USA; Department of Otolaryngology, Boston Medical Center, 800 Harrison Avenue, Boston, MA 02118, USA. Electronic address: gintas@bu.edu.