Integrating single-cell RNA-Seq and machine learning to dissect tryptophan metabolism in ulcerative colitis.

Journal: Journal of translational medicine
PMID: 39707393

Abstract

BACKGROUND: Ulcerative colitis (UC) is a persistent inflammatory bowels disease (IBD) characterized by immune response dysregulation and metabolic disruptions. Tryptophan metabolism has been believed as a significant factor in UC pathogenesis, with specific metabolites influencing immune modulation and gut microbiota interactions. However, the precise regulatory mechanisms and key genes involved remain unclear.

Authors

  • Guorong Chen
    Department of Pathology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
  • Hongying Qi
    Department of Spleen and Stomach Diseases of Traditional Chinese Medicine, China-Japan Friendship Hospital (Institute of Clinical Medical Sciences), Beijing, 100029, China.
  • Li Jiang
    School of Food Science and Engineering, Hefei University of Technology, Hefei, China.
  • Shijie Sun
    Department of Gastroenterology, China-Japan Friendship Hospital (Institute of Clinical Medical Sciences), Beijing, 100029, China.
  • Junhai Zhang
    Department of Gastroenterology, China-Japan Friendship Hospital (Institute of Clinical Medical Sciences), Beijing, 100029, China.
  • Jiali Yu
  • Fang Liu
    The First Clinical Medical College of Gannan Medical University, Ganzhou 341000, Jiangxi Province, China.
  • Yanli Zhang
    School of Information Science and Engineering, Shandong University, Jinan 250100, P. R. China.
  • Shiyu Du
    Engineering Laboratory of Advanced Energy Materials, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China.

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