Machine learning models for diagnosis and risk prediction in eating disorders, depression, and alcohol use disorder.

Journal: Journal of affective disorders
PMID:

Abstract

BACKGROUND: Early diagnosis and treatment of mental illnesses is hampered by the lack of reliable markers. This study used machine learning models to uncover diagnostic and risk prediction markers for eating disorders (EDs), major depressive disorder (MDD), and alcohol use disorder (AUD).

Authors

  • Zuo Zhang
    Collage of Public Administration, Central China Normal University, Wuhan 430079, China.
  • Lauren Robinson
    Department of Psychological Medicine, Centre for Research in Eating and Weight Disorders, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; South London and Maudsley NHS Foundation Trust, London, UK; Oxford Institute of Clinical Psychology Training and Research, Oxford University, Oxford, UK.
  • Robert Whelan
    School of Psychology and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland. robert.whelan@tcd.ie.
  • Lee Jollans
    School of Psychology and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
  • Zijian Wang
    School of Medical Informatics Engineering, Anhui University of Chinese Medicine, Hefei, Anhui 230012, China.
  • Frauke Nees
    Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159 Mannheim, Germany; Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, Mannheim, Germany.
  • Congying Chu
    Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, People's Republic of China.
  • Marina Bobou
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, London SE5 8AF, UK; Research Department of Clinical, Educational and Health Psychology, University College London, London, UK.
  • Dongping Du
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, London SE5 8AF, UK; Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA 22203, USA.
  • Ilinca Cristea
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, London SE5 8AF, UK.
  • Tobias Banaschewski
    Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159 Mannheim, Germany.
  • Gareth J Barker
    Department of Neuroimaging, Institute of Psychiatry, Psychology, & Neuroscience, King's College London, United Kingdom.
  • Arun L W Bokde
    Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Ireland.
  • Antoine Grigis
    NeuroSpin, CEA, Université Paris-Saclay, F-91191, Gif-sur-Yvette, France.
  • Hugh Garavan
    Departments of Psychiatry and Psychology, University of Vermont, 05405 Burlington, VT, USA.
  • Andreas Heinz
    Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charitéplatz 1, Berlin, Germany.
  • Rüdiger Brühl
    Physikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany.
  • Jean-Luc Martinot
    Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 "Neuroimaging & Psychiatry", University Paris Sud, University Paris Descartes - Sorbonne Paris Cité; and Maison de Solenn, Paris, France.
  • Marie-Laure Paillère Martinot
    Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 "Neuroimaging & Psychiatry", University Paris Sud, University Paris Descartes; Sorbonne Université; and AP-HP, Department of Child and Adolescent Psychiatry, Pitié-Salpêtrière Hospital, Paris, France.
  • Eric Artiges
    Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 "Neuroimaging & Psychiatry", University Paris Sud, University Paris Descartes - Sorbonne Paris Cité, and Psychiatry Department 91G16, Orsay Hospital, France.
  • Dimitri Papadopoulos Orfanos
    NeuroSpin, CEA, Université Paris-Saclay, F-91191 Gif-sur-Yvette, France.
  • Luise Poustka
    Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, von-Siebold-Str. 5, 37075 Göttingen, Germany.
  • Sarah Hohmann
    Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159 Mannheim, Germany.
  • Sabina Millenet
    Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159 Mannheim, Germany.
  • Juliane H Fröhner
    Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany.
  • Michael N Smolka
    Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany.
  • Nilakshi Vaidya
    Centre for Population Neuroscience and Stratified Medicine (PONS), Department of Psychiatry and Neuroscience, Charité Universitätsmedizin Berlin, Germany.
  • Henrik Walter
    Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Psychiatry and Psychotherapy, CCM, Berlin, German.
  • Jeanne Winterer
    Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charitéplatz 1, Berlin, Germany; Department of Education and Psychology, Freie Universität Berlin, Berlin, Germany.
  • M John Broulidakis
    Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK; Department of Psychology, College of Science, Northeastern University, Boston, MA, USA.
  • Betteke Maria van Noort
    Department of Psychology, MSB Medical School Berlin, Rüdesheimer Str. 50, 14197 Berlin, Germany.
  • Argyris Stringaris
    National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
  • Jani Penttilä
    Department of Social and Health Care, Psychosocial Services Adolescent Outpatient Clinic Kauppakatu 14, Lahti, Finland.
  • Yvonne Grimmer
    Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159 Mannheim, Germany.
  • Corinna Insensee
    Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, von-Siebold-Str. 5, 37075 Göttingen, Germany.
  • Andreas Becker
    Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, von-Siebold-Str. 5, 37075 Göttingen, Germany.
  • Yuning Zhang
    Psychology Department, B44 University Rd, University of Southampton, Southampton SO17 1PS, UK.
  • Sinead King
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, London SE5 8AF, UK; School of Medicine, Centre for Neuroimaging, Cognition and Genomics, National University of Ireland (NUI), Galway, Ireland; Beaumont Hospital, Royal College of Surgeons, Ireland.
  • Julia Sinclair
    Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
  • Gunter Schumann
    Centre for Population Neuroscience and Stratified Medicine (PONS), Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King's College London, London SE5 8AF, United Kingdom.
  • Ulrike Schmidt
    Department of Psychological Medicine, Centre for Research in Eating and Weight Disorders, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; South London and Maudsley NHS Foundation Trust, London, UK.
  • Sylvane Desrivières
    Centre for Population Neuroscience and Stratified Medicine (PONS), Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King's College London, London SE5 8AF, United Kingdom.