Exploratory study of extracellular matrix biomarkers for non-invasive liver fibrosis staging: A machine learning approach with XGBoost and explainable AI.

Journal: Clinical biochemistry
PMID: 39675656

Abstract

BACKGROUND: Novel circulating markers for the non-invasive staging of chronic liver disease (CLD) are in high demand. Although underutilized, extracellular matrix (ECM) components offer significant diagnostic potential. This study evaluates ECM-related markers in hepatitis C virus (HCV)-positive patients across varying fibrosis stages.

Authors

  • Valeria Carnazzo
    Dipartimento di Patologia Clinica, Ospedale Santa Maria Goretti, A.U.S.L. Latina, 04100 Latina, Italy.
  • Stefano Pignalosa
    Dipartimento di Patologia Clinica, Ospedale Santa Maria Goretti, A.U.S.L. Latina, 04100 Latina, Italy.
  • Marzia Tagliaferro
    Dipartimento di Patologia Clinica, Ospedale Santa Maria Goretti, A.U.S.L. Latina, 04100 Latina, Italy.
  • Laura Gragnani
    Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56126 Pisa, Italy.
  • Anna Linda Zignego
    Center for Systemic Manifestations of Hepatitis Viruses (MaSVE), Department of Experimental and Clinical Medicine, University of Florence, 50121 Florence, Italy.
  • Cosimo Racco
    Dipartimento di Patologia Clinica, Ospedale Santa Maria Goretti, A.U.S.L. Latina, 04100 Latina, Italy.
  • Luigi Di Biase
    Section Head Electrophysiology, Montefiore Medical Center, Albert Einstein College of Medicine, 111 E 210th street, Bronx, NY 10467, USA. Electronic address: dibbia@gmail.com.
  • Valerio Basile
    Clinical Pathology Unit and Cancer Biobank, Department of Research and Advanced Technologies, I.R.C.C.S. Regina Elena National Cancer Institute, 00144 Rome, Italy.
  • Gian Ludovico Rapaccini
    Fondazione Policlinico Universitario Agostino Gemelli I.R.C.C.S., 00168 Rome, Italy.
  • Riccardo Di Santo
    Dipartimento di Neuroscienze, Sezione di Fisica, Università Cattolica del Sacro Cuore, 00168 Rome, Italy; Dipartimento di Scienze della Vita, della salute e delle Professioni sanitarie, Link Campus University, Rome, Italy.
  • Benedetta Niccolini
    Dipartimento di Neuroscienze, Sezione di Fisica, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
  • Mariapaola Marino
    Fondazione Policlinico Universitario Agostino Gemelli I.R.C.C.S., 00168 Rome, Italy; Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy. Electronic address: mariapaola.marino@unicatt.it.
  • Marco De Spirito
    Fondazione Policlinico Universitario A. Gemelli IRCSS, Rome, Italy; Dipartimento di Neuroscienze, Università Cattolica Del Sacro Cuore, Rome, Italy.
  • Guido Gigante
    Istituto Superiore di Sanità, Rome, Italy.
  • Gabriele Ciasca
    Fondazione Policlinico Universitario Agostino Gemelli I.R.C.C.S., 00168 Rome, Italy; Dipartimento di Neuroscienze, Sezione di Fisica, Università Cattolica del Sacro Cuore, 00168 Rome, Italy. Electronic address: gabriele.ciasca@unicatt.it.
  • Umberto Basile
    Department of Laboratory Medicine, Università Cattolica del Sacro Cuore, Rome, Italy.

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