AIMC Topic: Extracellular Matrix

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FIRM image analysis: A machine learning workflow for quantifying extracellular matrix components from electron microscopy images.

PloS one Feb 6, 2025
The extracellular matrix (ECM) is a complex network of biomolecules that plays an integral role in the structure, processes, and signaling mechanisms of cells and tissues. Identifying and quantifying changes in these matrix components provides insigh...
Humans Machine Learning Software Workflow Extracellular Matrix Microscopy, Electron Animals Image Processing, Computer-Assisted Algorithms
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Machine learning identifies remodeling patterns in human lung extracellular matrix.

Acta biomaterialia Dec 31, 2024
Organ function depends on the three-dimensional integrity of the extracellular matrix (ECM). The structure resulting from the location and association of ECM components is a central regulator of cell behavior, but a dearth of matrix-specific analysis...
Humans Machine Learning COVID-19 Male Lung Extracellular Matrix Female SARS-CoV-2
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Exploratory study of extracellular matrix biomarkers for non-invasive liver fibrosis staging: A machine learning approach with XGBoost and explainable AI.

Clinical biochemistry Dec 13, 2024
BACKGROUND: Novel circulating markers for the non-invasive staging of chronic liver disease (CLD) are in high demand. Although underutilized, extracellular matrix (ECM) components offer significant diagnostic potential. This study evaluates ECM-relat...
Extracellular Matrix Boosting Machine Learning Algorithms Adult Male Biomarkers Middle Aged Female Humans Liver Cirrhosis Machine Learning Aged Hyaluronic Acid
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Combined High-Throughput Proteomics and Random Forest Machine-Learning Approach Differentiates and Classifies Metabolic, Immune, Signaling and ECM Intra-Tumor Heterogeneity of Colorectal Cancer.

Cells Aug 6, 2024
Colorectal cancer (CRC) is a frequent, worldwide tumor described for its huge complexity, including inter-/intra-heterogeneity and tumor microenvironment (TME) variability. Intra-tumor heterogeneity and its connections with metabolic reprogramming an...
Random Forest Extracellular Matrix Male Middle Aged Signal Transduction Epithelial-Mesenchymal Transition Proteomics Humans Aged Colorectal Neoplasms Tumor Microenvironment Machine Learning Female
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Perineuronal Net Microscopy: From Brain Pathology to Artificial Intelligence.

International journal of molecular sciences Apr 11, 2024
Perineuronal nets (PNN) are a special highly structured type of extracellular matrix encapsulating synapses on large populations of CNS neurons. PNN undergo structural changes in schizophrenia, epilepsy, Alzheimer's disease, stroke, post-traumatic co...
Synapses Brain Extracellular Matrix Animals Microscopy Nerve Net Humans Brain Diseases Neurons Artificial Intelligence
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Multimodal characterization of the collagen hydrogel structure and properties in response to physiologically relevant pH fluctuations.

Acta biomaterialia Feb 28, 2024
pH fluctuations within the extracellular matrix (ECM) and its principal constituent collagen, particularly in solid tumors and chronic wounds, may influence its structure and function. Whereas previous research examined the impact of pH on collagen f...
Artificial Intelligence Hydrogels Extracellular Matrix Collagen Type I Collagen
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Magnetic soft robotics to manipulate the extracellular matrix in vitro.

Cell Oct 31, 2023
The importance of dynamic mechanical control over the cellular microenvironment has long been appreciated. In a recent issue of Device, Raman and colleagues design a clever yet generalizable tool to achieve this, illustrating magnetic stimulation of ...
Magnetic Phenomena Extracellular Matrix Tissue Engineering Robotics
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Rapid prediction of lab-grown tissue properties using deep learning.

Physical biology Oct 19, 2023
The interactions between cells and the extracellular matrix are vital for the self-organisation of tissues. In this paper we present proof-of-concept to use machine learning tools to predict the role of this mechanobiology in the self-organisation of...
Tissue Scaffolds Neural Networks, Computer Machine Learning Hydrogels Extracellular Matrix Deep Learning Tissue Engineering
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Self-supervised classification of subcellular morphometric phenotypes reveals extracellular matrix-specific morphological responses.

Scientific reports Sep 12, 2022
Cell morphology is profoundly influenced by cellular interactions with microenvironmental factors such as the extracellular matrix (ECM). Upon adhesion to specific ECM, various cell types are known to exhibit different but distinctive morphologies, s...
Microscopy, Fluorescence Extracellular Matrix Phenotype Neural Networks, Computer Fibroblasts
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Predicting and understanding arterial elasticity from key microstructural features by bidirectional deep learning.

Acta biomaterialia May 25, 2022
Microstructural features and mechanical properties are closely related in all soft biological tissues. Both yet exhibit considerable inter-individual differences and are affected by factors such as aging and disease and its progression. Histological ...
Extracellular Matrix Deep Learning Biomechanical Phenomena Arteries Mice Elasticity Stress, Mechanical Animals Collagen
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