Proceedings of the National Academy of Sciences of the United States of America
Nov 21, 2025
Cells in tissues navigate fibrous environments fundamentally differently than they do on flat substrates, but the establishment of cell forces in physiological fibrous settings remains poorly understood. Although factors such as the stiffness of the ...
Biomedical materials (Bristol, England)
Nov 7, 2025
Cancer is among the major causes of mortality, responsible for approximately 15% of all deaths worldwide. Despite remarkable progress in modern medicine, it remains a significant global health challenge. Nevertheless, conventional therapies such as c...
Deep learning for protein function prediction faces significant challenges in identifying disease-specific proteins. We present Extracellular Matrix Protein Predictor (EPOP), an advanced transfer learning framework leveraging protein language models ...
Biochemical and biophysical research communications
Oct 4, 2025
The extracellular matrix (ECM) is crucial in tuning cellular behavior, and quantifying cellular mechanical changes in response to ECM stimuli can help reveal the underlying physical mechanisms of cell-ECM interactions for a comprehensive understandin...
Biomedical materials (Bristol, England)
Oct 3, 2025
The global rise in chronic kidney disease necessitates innovative solutions for end-stage renal disease that can help to overcome the limitations of the only available treatment options, transplantation and dialysis. Tissue engineering presents a pro...
OBJECTIVE: This research aims to detect genes associated with the extracellular matrix (ECM) in idiopathic pulmonary fibrosis (IPF) using bioinformatics techniques and investigate their relationships with immune infiltration, with the goal of identif...
Squamous cell carcinoma (SCC) and high-grade dysplasia (HGD) are two different pathological entities; however, they sometimes share similarities in histological structure depending on the context. Thus, distinguishing between the two may require care...
The mortality rates have been increasing for glioma in adolescents and young adults (AYAs, aged 15-39 years). However, current biomarkers for clinical assessment in AYAs glioma are limited, prompting the urgent need for identifying ideal prognostic s...
The tumor microenvironment plays a critical role in tumor progression and immune response, with the extracellular matrix (ECM) regulating immune cell infiltration. However, the interplay between ECM dynamics and tumor immunity remains poorly understo...
The extracellular matrix (ECM) is a complex network of biomolecules that plays an integral role in the structure, processes, and signaling mechanisms of cells and tissues. Identifying and quantifying changes in these matrix components provides insigh...
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