Longitudinal serological proteomic dynamics during antiviral therapy (AVT) in chronic hepatitis B (CHB) patients with liver fibrosis remain poorly characterized. Here, using four-dimensional data-independent acquisition mass spectrometry (4D-DIA-MS),...
BACKGROUND: Hepatic encephalopathy (HE) contributes significantly to mortality among patients with liver cirrhosis. Early prediction of HE is essential for clinical decision-making, yet remains challenging-particularly in noncancer-related cirrhosis ...
Patients with cirrhosis face an elevated risk of developing sepsis, leading to an escalating mortality rate. This study focuses on the link between natural killer (NK) cells, cirrhosis, and sepsis. Our goal is to identify NK cell-related genes that c...
This study employed machine learning models to quantitatively analyze liver fat content from MRI images for the evaluation of liver fibrosis and disease severity in patients with metabolic dysfunction-associated fatty liver disease (MAFLD). A total o...
Liver cirrhosis (LC) is a common chronic disease worldwide with a poor prognosis, and its pathogenesis has not been fully elucidated. Toll-like receptors (TLRs) are crucial in LC progression. Here, we identified TLR-related genes, providing novel ins...
Cirrhosis care is inherently complex, marked by a high risk of acute decompensation and significant morbidity and mortality. Traditional episodic care models provide static snapshots of a patient's condition, limiting the ability to address dynamic c...
BACKGROUND: Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and the third most common cause of cancer-related death. Cirrhosis is a major contributing factor, accounting for over 90% of HCC cases. With the high mortality rate...
BACKGROUND: The transjugular intrahepatic portosystemic shunt (TIPS), a crucial tool for treating complications related to portal hypertension in patients with liver cirrhosis, is often associated with an increased risk of postoperative complications...
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