Volumetric Breast Density Estimation From Three-Dimensional Reconstructed Digital Breast Tomosynthesis Images Using Deep Learning.

Journal: JCO clinical cancer informatics
Published Date: Dec 9, 2024

Abstract

PURPOSE: Breast density is a widely established independent breast cancer risk factor. With the increasing utilization of digital breast tomosynthesis (DBT) in breast cancer screening, there is an opportunity to estimate volumetric breast density (VBD) routinely. However, current available methods extrapolate VBD from two-dimensional (2D) images acquired using DBT and/or depend on the existence of raw DBT data, which is rarely archived by clinical centers because of storage constraints.

Authors

  • Vinayak S Ahluwalia
    Department of Radiology, Center for Biomedical Image Computing and Analytics (CBICA), University of Pennsylvania, Philadelphia, PA, 19104, USA.
  • Nehal Doiphode
    Department of Radiology, Columbia University Irving Medical Center, New York, NY.
  • Walter C Mankowski
    Department of Radiology, Columbia University Irving Medical Center, New York, NY.
  • Eric A Cohen
    Center for Biomedical Image Computing and Analytics (CBICA), University of Pennsylvania, Philadelphia, PA.
  • Sarthak Pati
    Perelman School of Medicine, Philadelphia, PA, USA.
  • Lauren Pantalone
    Department of Radiology, Perelman School of Medicine, University of Pennsylvania, 3710 Hamilton Walk, Rm D601E Goddard Bldg., Philadelphia, PA 19104.
  • Spyridon Bakas
    Perelman School of Medicine, Philadelphia, PA, USA.
  • Ari Brooks
    Department of Surgery, Division of Endocrine and Oncologic Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA.
  • Celine M Vachon
  • Emily F Conant
    Department of Radiology, Perelman School of Medicine at the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104 (E.F.C.); Biostatistics Consulting, Kensington, Md (A.Y.T.); iCAD, Nashua, NH (S.P., S.V.F., J.G., J.W.H.); and Intrinsic Imaging, Bolton, Mass (J.E.B.).
  • Aimilia Gastounioti
    Breast Image Computing Lab, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, United States.
  • Despina Kontos
    Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, United States.

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