Machine learning based metabolomic and genetic profiles for predicting multiple brain phenotypes.

Journal: Journal of translational medicine
PMID:

Abstract

BACKGROUND: It is unclear regarding the association between metabolomic state/genetic risk score(GRS) and brain volumes and how much of variance of brain volumes is attributable to metabolomic state or GRS.

Authors

  • Xueli Zhang
    Center for Systems Biology, Soochow University, Suzhou 215006, Jiangsu, China.
  • Yu Huang
    School of Data Science and Software Engineering, Qingdao University, Qingdao 266021, China.
  • Shunming Liu
    Department of Ophthalmology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
  • Shuo Ma
    College of Fine Arts and Design, Hebei Institute of Communications, ShiJiazhuang 050000, China.
  • Min Li
    Hubei Provincial Institute for Food Supervision and Test, Hubei Provincial Engineering and Technology Research Center for Food Quality and Safety Test, Wuhan 430075, China.
  • Zhuoting Zhu
    Department of Ophthalmology, Guangdong Academy of Medical Sciences, Guangdong Provincial People's Hospital, Guangzhou, China.
  • Wei Wang
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, China.
  • Xiayin Zhang
    State Key Laboratory of Ophthalmology, Clinical Research Center for Ocular Disease, Zhongshan Ophthalmic Centre, Sun Yat-sen University, Guangzhou, China.
  • Jiahao Liu
    School of Artificial Intelligence, Hebei University of Technology, Tianjin, 300130, China.
  • Shulin Tang
    Department of Ophthalmology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
  • Yijun Hu
    Aier Institute of Refractive Surgery, Refractive Surgery Center, Guangzhou Aier Eye Hospital, Guangzhou, China.
  • Zongyuan Ge
    AIM for Health Lab, Faculty of IT, Monash University, Clayton, Victoria, Australia; Monash-Airdoc Research Lab, Faculty of IT, Monash University, Clayton, Victoria, Australia.
  • Honghua Yu
    Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, the Second School of Clinical Medicine, Southern Medical University, Guangzhou, China.
  • Mingguang He
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China; Centre for Eye Research Australia; Departments of Ophthalmology and Surgery, University of Melbourne, Melbourne, Australia. Electronic address: mingguang.he@unimelb.edu.au.
  • Xianwen Shang
    Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia.