Exploring Schizophrenia Classification Through Multimodal MRI and Deep Graph Neural Networks: Unveiling Brain Region-Specific Weight Discrepancies and Their Association With Cell-Type Specific Transcriptomic Features.

Journal: Schizophrenia bulletin
Published Date: Dec 20, 2024

Abstract

BACKGROUND AND HYPOTHESIS: Schizophrenia (SZ) is a prevalent mental disorder that imposes significant health burdens. Diagnostic accuracy remains challenging due to clinical subjectivity. To address this issue, we explore magnetic resonance imaging (MRI) as a tool to enhance SZ diagnosis and provide objective references and biomarkers. Using deep learning with graph convolution, we represent MRI data as graphs, aligning with brain structure, and improving feature extraction, and classification. Integration of multiple modalities is expected to enhance classification.

Authors

  • Jingjing Gao
    School of Electronic Engineering, University of Electronic Science and Technology of China, Xiyuan Ave. 2006, West Hi-Tech Zone, Chengdu, Sichuan, 611731, China.
  • Maomin Qian
    School of Information and Communication Engineering, University of Electronic Science and Technology of China, Chengdu, China.
  • Zhengning Wang
    School of Information and Communication Engineering, University of Electronic Science and Technology of China, Chengdu 611731, China.
  • Yanling Li
    School of Mathematics and Statistics, North China University of Water Resources and Electric Power, Zhengzhou 450046, China.
  • Na Luo
    Brainnetome Center and National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China.
  • Sangma Xie
    Institute of Biomedical Engineering and Instrumentation, School of Automation, Hangzhou Dianzi University, Hangzhou, China.
  • Weiyang Shi
  • Peng Li
    WuXi AppTec Co, Shanghai, China.
  • Jun Chen
    Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Yunchun Chen
    Department of Psychiatry, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, Shaanxi, China.
  • Huaning Wang
    Department of Psychiatry, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
  • Wenming Liu
    Department of Psychiatry, Xijing Hospital, The Fourth Military Medical University, Xi'an, China.
  • Zhigang Li
    Hefei Institute of Physical Science, Chinese Academy of Sciences Hefei 230036 PR China liuyong@aiofm.ac.cn zhanglong@aiofm.ac.cn wangchongwen1987@126.com.
  • Yongfeng Yang
    Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055 China.
  • Hua Guo
    Zhumadian Psychiatric Hospital, Zhumadian 463000, Henan, China.
  • Ping Wan
    Zhumadian Psychiatric Hospital, Zhumadian 463000, Henan, China.
  • Luxian Lv
    Henan Key Laboratory of Biological Psychiatry, Henan Mental Hospital, Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, China.
  • Lin Lu
    School of Economics and Management, Guangxi Normal University, Guilin, China.
  • Jun Yan
    Department of Statistics, University of Connecticut, Storrs, CT 06269, USA.
  • Yuqing Song
    School of Computer Science and Communication Engineering, Jiangsu University, Zhenjiang 212013, China.
  • Huiling Wang
    Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei, China.
  • Hongxing Zhang
    Department of Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang 453002, Henan, China; Department of Psychology, Xinxiang Medical University, Xinxiang 453002, Henan, China.
  • Huawang Wu
    The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China.
  • Yuping Ning
  • Yuhui Du
    The Mind Research Network, NM, USA; Shanxi University, School of Computer & Information Technology, Taiyuan, China.
  • Yuqi Cheng
    Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, China.
  • Jian Xu
    Department of Cardiology, Lishui Central Hospital and the Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, China.
  • Xiufeng Xu
    Nycrist Pharmatech Limited, 2/2D, A3, Science and Technology Park, 3009 Guanguang Rd, Guangming, Shenzhen, Guangdong 518107, China.
  • Dai Zhang
    Institute of Mental Health, Key Laboratory of Mental Health, Ministry of Health & National Clinical Research Center for Mental Disorders, Sixth Hospital, Peking University, Beijing, China.
  • Tianzai Jiang
    Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing, China.

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