Prediction and validation of anoikis-related genes in neuropathic pain using machine learning.

Journal: PloS one
PMID: 40014587

Abstract

BACKGROUND: Neuropathic pain (NP) can be induced by a variety of clinical conditions, such as spinal cord injury, lumbar disc herniation (LDH), lumbar spinal stenosis, diabetes, herpes zoster, and spinal cord tumors, and inflammatory stimuli. The pathogenesis of NP is extremely complex. Specifically, in LDH, the herniated nucleus pulposus exerts mechanical pressure on nerve roots, triggering local inflammation and consequent NP. Anoikis, a special form of programmed cell death, is closely related to the progression of NP. In this study, we sought to clarify the molecular characteristics of anoikis-related genes in NP, providing novel insights for the diagnosis and treatment of NP.

Authors

  • Yufeng He
    Guangdong Laboratory of Artificial Intelligence and Digital Economy (SZ), Shenzhen University, Guangdong Province, PR China.
  • Ye Wei
    Max-Planck-Institut für Eisenforschung GmbH, Max-Planck-Straße 1, Düsseldorf, Germany.
  • Yongxin Wang
    School of Measurement and Control Technology and Communication Engineering, Harbin University of Science and Technology, Harbin 150080, China.
  • Chunyan Ling
    Department of Rehabilitation Medicine, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning, China.
  • Xiang Qi
    Graduate School, Henan University of Chinese Medicine, Zhengzhou, China.
  • Siyu Geng
    Second Clinical Medical College, Henan University of Chinese Medicine, Zhengzhou, China.
  • Yingtong Meng
    Graduate School, Guangxi University of Chinese Medicine, Nanning, China.
  • Hao Deng
    Faculty of Information Technology, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau, China.
  • Qisong Zhang
    School of Information and Business Management, Dalian Neusoft University of Information, Dalian 116000, Liaoning, China.
  • Xiaoling Qin
    School of Pharmacy, Guangxi University of Chinese Medicine, Nanning, China.
  • Guanghui Chen
    Department of Orthopedics, Peking University Third Hospital, Beijing, China.

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