The aim of this study was to develop a combined deep-learning model utilizing liver ultrasound, liver elastography images, and clinical features to predict and diagnose fibrotic non-alcoholic steatohepatitis (NASH). A rat model of liver steatosis and...
Hypertension is a leading cause of mortality worldwide, for which myriad treatment options are available. It is widely considered that continuous measurement of arterial blood pressure (BP) could improve the treatment of hypertension; however, chroni...
Journal of controlled release : official journal of the Controlled Release Society
Nov 17, 2025
Long-acting injectables (LAIs) represent promising drug delivery platforms for chronic diseases management, but their clinical translation remains constrained by extremely long trial-and-error experiments (8-10 years), limited mechanism insights, and...
Journal of molecular neuroscience : MN
Nov 15, 2025
Spinal cord injury (SCI), a traumatic type of central nervous system injury, is closely associated with neuronal apoptosis. However, the specific biomarkers and regulatory mechanisms of neuronal apoptosis in SCI patients remain unclear. In this study...
Amphetamine has widespread effects on multiple neurotransmitter systems, potentially altering the physiological connectivity and network dynamics across various regions of the brain. In this study, we investigated the effects of D-amphetamine using o...
Cellular and molecular life sciences : CMLS
Oct 30, 2025
The interaction between spinal cord neural networks and myocytes in postnatal mammals plays a crucial role in development, and the neural regulation of motor and visceral functions. Here, spinal cord neural network tissue (SC-NNT) was constructed wit...
Alzheimer's disease (AD) is characterized by progressive neurodegeneration, synaptic dysfunction, and cognitive decline. Regenerative strategies aim to replace lost neurons and modulate the inflammatory milieu to restore neural networks. This study e...
The inherently constrained regenerative capacity of neuronal tissue poses a major obstacle to repairing traumatic brain injury. While neural stem cell transplantation holds promise, its efficacy is constrained by slow and inefficient neuronal differe...
BACKGROUND: Coronary Microvascular Dysfunction (CMD) represents a critical pathological substrate for ischemic heart disease and is strongly associated with major adverse cardiovascular events. Zacopride, known for its dual cardiovascular regulatory ...
Ciprofloxacin (CFX) is a potent antibiotic for respiratory infections, but its poor solubility and high crystallinity limit its effectiveness in dry powder inhaler (DPI) delivery. Although soluble forms such as CFX hydrochloride are available, their ...
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