Enhancing surgical precision in squamous cell carcinoma of the head and neck: Hyperspectral imaging and artificial intelligence for improved margin assessment in an ex vivo setting.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
PMID: 39923711

Abstract

BACKGROUND: Head and neck cancers, constituting 3-5% of all cancer cases, often require surgical resection for optimal outcomes. Achieving complete resection (R0) is crucial, but current methods, relying on white light endoscopy and microscopy, have limitations. Hyperspectral imaging (HSI) offers potential benefits by capturing detailed spectral information beyond human vision.

Authors

  • Felix Boehm
    Department of Otorhinolaryngology, Head and Neck Surgery, Ulm University Medical Center, Frauensteige 12, 89075 Ulm, Germany; Surgical Oncology Ulm, i2SOUL Consortium, Germany. Electronic address: felix.boehm@uniklinik-ulm.de.
  • Anna Alperovich
    Carl Zeiss AG, Corporate Research and Technology, Carl-Zeiss-Str. 22, 73447 Oberkochen, Germany.
  • Carolin Schwamborn
    Department of Otorhinolaryngology, Head and Neck Surgery, Ulm University Medical Center, Frauensteige 12, 89075 Ulm, Germany; Surgical Oncology Ulm, i2SOUL Consortium, Germany.
  • Mayar Mostafa
    Carl Zeiss Meditec AG, Rudolf-Eber-Str.11, 73447 Oberkochen, Germany.
  • Tommaso Giannantonio
    Carl Zeiss AG, Corporate Research and Technology, Carl-Zeiss-Str. 22, 73447 Oberkochen, Germany.
  • Julia Lingl
    Department of Otorhinolaryngology, Head and Neck Surgery, Ulm University Medical Center, Frauensteige 12, 89075 Ulm, Germany; Surgical Oncology Ulm, i2SOUL Consortium, Germany.
  • RenĂ© Lehner
    Department of Otorhinolaryngology, Head and Neck Surgery, Ulm University Medical Center, Frauensteige 12, 89075 Ulm, Germany; Surgical Oncology Ulm, i2SOUL Consortium, Germany.
  • Xiaohan Zhang
    Division of Health Sciences Informatics, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America.
  • Thomas K Hoffmann
  • Patrick J Schuler
    Department of Otorhinolaryngology, University of Ulm, Ulm, Germany.

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