PSMA PET/CT based multimodal deep learning model for accurate prediction of pelvic lymph-node metastases in prostate cancer patients identified as candidates for extended pelvic lymph node dissection by preoperative nomograms.

Journal: European journal of nuclear medicine and molecular imaging
PMID:

Abstract

PURPOSE: To develop and validate a prostate-specific membrane antigen (PSMA) PET/CT based multimodal deep learning model for predicting pathological lymph node invasion (LNI) in prostate cancer (PCa) patients identified as candidates for extended pelvic lymph node dissection (ePLND) by preoperative nomograms.

Authors

  • Qiaoke Ma
    Department of Nuclear Medicine, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha, Hunan, 410008, P.R. China.
  • Bei Chen
    Department of Urban Studies and Planning, University of Sheffield, Sheffield, UK.
  • Robert Seifert
    Department of Nuclear Medicine, Medical Faculty, University Hospital Essen, Essen, Deutschland.
  • Rui Zhou
    College of New Energy and Environment, Jilin University, Changchun 130021, China.
  • Ling Xiao
    Cardiovascular Disease Initiative and Precision Cardiology Laboratory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Jinhui Yang
    Department of Nuclear Medicine, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha, Hunan, 410008, P.R. China.
  • Axel Rominger
  • Kuangyu Shi
    Universitätsklinik für Nuklearmedizin, Inselspital University Hospital Bern, University of Bern, Bern, Switzerland.
  • Weikai Li
  • Yongxiang Tang
    Department of Nuclear Medicine, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha, Hunan, 410008, P.R. China. xyyf0401@qq.com.
  • Shuo Hu
    School of Computer Science and Technology, Wuhan University of Science and Technology, Wuhan, Hubei, China.