Deep Learning-Enabled Assessment of Right Ventricular Function Improves Prognostication After Transcatheter Edge-to-Edge Repair for Mitral Regurgitation.

Journal: Circulation. Cardiovascular imaging
PMID: 39836730

Abstract

BACKGROUND: Right ventricular (RV) function has a well-established prognostic role in patients with severe mitral regurgitation (MR) undergoing transcatheter edge-to-edge repair (TEER) and is typically assessed using echocardiography-measured tricuspid annular plane systolic excursion. Recently, a deep learning model has been proposed that accurately predicts RV ejection fraction (RVEF) from 2-dimensional echocardiographic videos, with similar diagnostic accuracy as 3-dimensional imaging. This study aimed to evaluate the prognostic value of the deep learning-predicted RVEF values in patients with severe MR undergoing TEER.

Authors

  • Mark Lachmann
    Department of Cardiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
  • Vera Fortmeier
    Department of General and Interventional Cardiology, Heart and Diabetes Center Northrhine-Westfalia, Ruhr University Bochum, Bad Oeynhausen, Germany (V.F., M.F., M.G., V.R.).
  • Lukas Stolz
    Medizinische Klinik und Poliklinik I, Klinikum der Universität München, Ludwig Maximilians University of Munich, Germany (L.S., J.H.).
  • Márton Tokodi
    Division of Cardiology, West Virginia University Heart & Vascular Institute, Morgantown, West Virginia.
  • Attila Kovács
    University of Szeged, Interdisciplinary Excellence Centre, Hungary.
  • Amelie Hesse
    First Department of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany (M.L., A.H., E.R., J.T., K.-L.L.).
  • Antonia Leipert
    Department of Cardiology (A.L., H.A.A.C., M.v.S., F.R., A. Kastrati, H.S., M.J., E.X., T.T.), German Heart Center Munich, Technical University of Munich, Munich, Germany.
  • Elena Rippen
    First Department of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany (M.L., A.H., E.R., J.T., K.-L.L.).
  • Héctor Alfonso Alvarez Covarrubias
    Department of Cardiology (A.L., H.A.A.C., M.v.S., F.R., A. Kastrati, H.S., M.J., E.X., T.T.), German Heart Center Munich, Technical University of Munich, Munich, Germany.
  • Moritz von Scheidt
    DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance (M.L., A.H., E.R., M.v.S., A. Kastrati, H.S., M.J., E.X., K.-L.L., J.H., T.T.).
  • Jule Tervooren
    First Department of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany (M.L., A.H., E.R., J.T., K.-L.L.).
  • Ferdinand Roski
    Department of Cardiology (A.L., H.A.A.C., M.v.S., F.R., A. Kastrati, H.S., M.J., E.X., T.T.), German Heart Center Munich, Technical University of Munich, Munich, Germany.
  • Michelle Fett
    Department of General and Interventional Cardiology, Heart and Diabetes Center Northrhine-Westfalia, Ruhr University Bochum, Bad Oeynhausen, Germany (V.F., M.F., M.G., V.R.).
  • Muhammed Gerçek
    Clinic for General and Interventional Cardiology/Angiology, Herz- und Diabeteszentrum, NRW, Ruhr-Universität Bochum, Medizinische Fakultät OWL (Universität Bielefeld), Bad Oeynhausen, Germany.
  • Tibor Schuster
    Clinical Epidemiology and Biostatistics Unit, Murdoch Children's Research Institute, Melbourne, VIC, Australia; Department of Family Medicine, McGill University, Montreal, QC, Canada.
  • Gerhard Harmsen
    Department of Physics, University of Johannesburg, Auckland Park, South Africa (G.H.).
  • Shinsuke Yuasa
    Department of Cardiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. Electronic address: yuasa@keio.jp.
  • N Patrick Mayr
    Institute of Anesthesiology (N.P.M.), German Heart Center Munich, Technical University of Munich, Munich, Germany.
  • Adnan Kastrati
    DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance (M.L., A.H., E.R., M.v.S., A. Kastrati, H.S., M.J., E.X., K.-L.L., J.H., T.T.).
  • Heribert Schunkert
    Deutsches Herzzentrum München, Technische Universität München, München, Germany.
  • Michael Joner
    DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance (M.L., A.H., E.R., M.v.S., A. Kastrati, H.S., M.J., E.X., K.-L.L., J.H., T.T.).
  • Erion Xhepa
    DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance (M.L., A.H., E.R., M.v.S., A. Kastrati, H.S., M.J., E.X., K.-L.L., J.H., T.T.).
  • Karl-Ludwig Laugwitz
    Department of Medicine I, School of Medicine & Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675, Munich, Germany.
  • Jörg Hausleiter
    DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance (M.L., A.H., E.R., M.v.S., A. Kastrati, H.S., M.J., E.X., K.-L.L., J.H., T.T.).
  • Volker Rudolph
    Clinic for General and Interventional Cardiology/Angiology, Herz- und Diabeteszentrum, NRW, Ruhr-Universität Bochum, Medizinische Fakultät OWL (Universität Bielefeld), Bad Oeynhausen, Germany.
  • Teresa Trenkwalder
    DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance (M.L., A.H., E.R., M.v.S., A. Kastrati, H.S., M.J., E.X., K.-L.L., J.H., T.T.).

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