Uncovering the epigenetic regulatory clues of PRRT1 in Alzheimer's disease: a strategy integrating multi-omics analysis with explainable machine learning.

Journal: Alzheimer's research & therapy
PMID:

Abstract

BACKGROUND: Alzheimer's disease (AD) is a complex neurodegenerative disorder with a largely unexplored epigenetic landscape.

Authors

  • Fang Wang
    Key Laboratory of Intelligent Computing and Information Processing of Ministry of Education and Hunan Key Laboratory for Computation and Simulation in Science and Engineering, Xiangtan University, Xiangtan, China.
  • Ying Liang
    Department of Therapeutic Radiology, Yale University, New Haven, CT, U.S.A.
  • Qin-Wen Wang
    Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, China.