AIMC Topic: Epigenesis, Genetic
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Advancements in the investigation of the mechanisms underlying cognitive aging.
Biogerontology
Aug 10, 2025
Cognitive aging, a pivotal domain at the intersection of neuroscience and psychology, exhibits a strong association with neurodegenerative disorders; however, its comprehensive underlying mechanisms remain incompletely elucidated. This review aims to...
Circulating epigenetic signatures classifying brain insulin resistance in humans.
Science translational medicine
Aug 6, 2025
Brain insulin action plays an important role in metabolic and cognitive health, but there is no biomarker available to assess brain insulin resistance in humans. Here, we developed a machine learning framework based on blood DNA methylation profiles ...
Epigenomic diagnosis and prognosis of Acute Myeloid Leukemia.
Nature communications
Jul 29, 2025
Despite the critical role of DNA methylation, clinical implementations harnessing its promise have not been described in acute myeloid leukemia. Utilizing DNA methylation from 3314 leukemia patient samples across 11 harmonized cohorts, we describe th...
Advancements in DNA methylation technologies and their application in cancer diagnosis.
Epigenetics
Jul 28, 2025
DNA methylation is a common epigenetic modification that maintains the integrity of the DNA sequence while profoundly influencing gene expression and phenotypic variation. Aberrant DNA methylation has been associated with the onset and progression of...
A multi-omic single-cell landscape reveals transcription and epigenetic regulatory features of t(8;21) AML.
Journal of translational medicine
Jul 24, 2025
BACKGROUND: Comprehensive analysis of single-cell transcriptome and chromatin accessibility will contribute to interpret the heterogeneity of acute myeloid leukemia (AML). We hypothesize that integrating single-cell transcriptomic and chromatin acces...
Precision nutrition in epigenetic aging: SHAP-optimized machine learning identifies omega-3 constituent-specific associations with aging biomarkers.
Biogerontology
Jul 24, 2025
This cross-sectional investigation seeks to examine the association between dietary omega-3 fatty acids (including α-linolenic acid [ALA], eicosapentaenoic acid [EPA], and docosahexaenoic acid [DHA]) and biomarkers of cellular aging, specifically DNA...
Distribution patterns of N6-methyladenine in the rye genome.
Scientific reports
Jul 18, 2025
N6-methyladenine (6 mA) has emerged as a potential epigenetic marker in eukaryotic genomes, yet its precise distribution patterns and biological functions in plant genomes are still not fully understood. In this study, we investigated the occurrence,...
Inflammation-related 5-hydroxymethylation signatures as markers for clinical presentations of coronary artery disease.
Cardiovascular diabetology
Jun 23, 2025
BACKGROUND: Coronary angiography remains the gold standard for diagnosing coronary artery disease (CAD), but its invasive nature limits its applicability for widespread screening. Identifying non-invasive molecular markers could improve CAD classific...
Female
Epigenesis, Genetic
Reproducibility of Results
Non-ST Elevated Myocardial Infarction
Inflammation
Aged
Inflammation Mediators
Middle Aged
Predictive Value of Tests
DNA Methylation
Male
5-Methylcytosine
Risk Assessment
ST Elevation Myocardial Infarction
Humans
Cell-Free Nucleic Acids
Severity of Illness Index
Coronary Artery Disease
Machine Learning
Biomarkers
Prognosis
Artificial Intelligence in cancer epigenomics: a review on advances in pan-cancer detection and precision medicine.
Epigenetics & chromatin
Jun 14, 2025
DNA methylation is a fundamental epigenetic modification that regulates gene expression and maintains genomic stability. Consequently, DNA methylation remains a key biomarker in cancer research, playing a vital role in diagnosis, prognosis, and tailo...
Integrative analysis of epigenetic and transcriptional interrelations identifies histotype-specific biomarkers in early-stage ovarian carcinoma.
Journal of ovarian research
May 19, 2025
BACKGROUND: Epithelial ovarian cancer (EOC) is a deadly and heterogenous disease comprising five major histotypes: clear cell carcinoma (CCC), endometrioid carcinoma (EC), low- and high-grade serous carcinoma (LGSC, HGSC), and mucinous carcinoma (MC)...
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