Convolutional Neural Networks for the segmentation of hippocampal structures in postmortem MRI scans.

Journal: Journal of neuroscience methods
PMID:

Abstract

BACKGROUND: The hippocampus plays a crucial role in memory and is one of the first structures affected by Alzheimer's disease. Postmortem MRI offers a way to quantify the alterations by measuring the atrophy of the inner structures of the hippocampus. Unfortunately, the manual segmentation of hippocampal subregions required to carry out these measures is very time-consuming.

Authors

  • Anoop B N
    Neuroimage Analytics Laboratory and Biggs Institute Neuroimaging Core, Glenn Biggs Institute for Neurodegenerative Disorders, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA; Department of Information and Communication Technology, Manipal Institute of Technology, Manipal, Manipal Academy of Higher Education (MAHE), Manipal, Karnaaka, 576104, India.
  • Karl Li
    Neuroimage Analytics Laboratory and Biggs Institute Neuroimaging Core, Glenn Biggs Institute for Neurodegenerative Disorders, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
  • Nicolas Honnorat
    Center for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, USA. Electronic address: Nicolas.Honnorat@uphs.upenn.edu.
  • Tanweer Rashid
    Center for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Di Wang
    Center for Endocrine Metabolism and Immune Diseases, Beijing Luhe Hospital, Capital Medical University, Beijing, People's Republic of China.
  • Jinqi Li
    Department of Orthopaedic Trauma, Beijing Jishuitan Hospital, Beijing, 100035, P. R. China.
  • Elyas Fadaee
    Neuroimage Analytics Laboratory and Biggs Institute Neuroimaging Core, Glenn Biggs Institute for Neurodegenerative Disorders, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
  • Sokratis Charisis
    Neuroimage Analytics Laboratory and Biggs Institute Neuroimaging Core, Glenn Biggs Institute for Neurodegenerative Disorders, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
  • Jamie M Walker
    Department of Pathology, University of Texas Health Science Center, San Antonio, TX, USA.
  • Timothy E Richardson
    Neuropathology Laboratory, Department of Pathology, UT Southwestern Medical Center, Dallas, TX, 75390, USA.
  • David A Wolk
    Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA.
  • Peter T Fox
    Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
  • José E Cavazos
    Neuroimage Analytics Laboratory and Biggs Institute Neuroimaging Core, Glenn Biggs Institute for Neurodegenerative Disorders, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA; Department of Neurology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
  • Sudha Seshadri
    The Framingham Heart Study, Framingham, MA 01701, USA.
  • Laura E M Wisse
    Penn Image Computing and Science Laboratory (PICSL), Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States; Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States; Department of Diagnostic Radiology, Lund University, Lund, Sweden.
  • Mohamad Habes
    Biggs Alzheimer's Institute, University of Texas San Antonio Health Science Center, USA.