A systematic exposure-wide framework leveraging machine learning to identify multidomain exposure factors and their joint influence on cognitive function: Evidence from a neurological cohort.

Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association
PMID:

Abstract

INTRODUCTION: Cognitive decline has become a growing public concern, yet large-scale exposure data identifying the contributing factors remain limited.

Authors

  • Jingtao Wu
    Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China.
  • Bowen Yin
    Department of Neurology, The First Hospital of Qinhuangdao, Hebei Medical University, Qinhuangdao, China.
  • Rui Wen
    Department of Nutrition and Food Hygiene, School of Public Health, Hebei Medical University, Hebei Key Laboratory of Environment and Human Health, Shijiazhuang, China.
  • Huanting Pei
    Department of Nutrition and Food Hygiene, School of Public Health, Hebei Medical University, Hebei Key Laboratory of Environment and Human Health, Shijiazhuang, China.
  • Siqi Zhu
    Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications, Jinan University, Guangzhou, China.
  • Jiaxin Zhao
    Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China.
  • Yanbing Li
    Department of Endocrinology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
  • Ming Yang
    Wuhan Institute for Food and Cosmetic Control, Wuhan 430014, China.
  • Yaoyu Hu
    Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China.
  • Qun Xu
    Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China.
  • Ang Li
    Section of Hematology-Oncology, Department of Medicine, Baylor College of Medicine, Houston, Texas; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington. Electronic address: ang.li2@bcm.edu.
  • Yuxia Ma
    Department of Nutrition and Food Hygiene, School of Public Health, Hebei Medical University, Hebei Key Laboratory of Environment and Human Health, Shijiazhuang, China.