Coupling analysis of diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) with abnormal cerebral blood flow in methamphetamine-dependent patients and its application in machine-learning-based classification.

Journal: Journal of affective disorders
PMID: 39961448

Abstract

BACKGROUND: Diffusion tensor imaging (DTI) analysis along the perivascular space (ALPS) index is currently widely employed to evaluate the neurophysiological activity in various neuropsychiatric disorders. However, there remains a scarcity of studies assessing the DTI-ALPS index in individuals with methamphetamine (MA) dependence. Recent studies on animals have demonstrated a significant correlation between glymphatic activity and alterations in cerebral blood flow (CBF). Hence, investigating the DTI-ALPS index and its coupling with CBF could yield novel insights for MA-dependent patients.

Authors

  • Ping Cheng
    Department of Emergency Surgery.
  • Yadi Li
    Department of Radiology, Ningbo Medical Center Lihuili Hospital, Ningbo University, Ningbo, China.
  • Shuyuan Wang
    Whiting School of Engineering, Johns Hopkins University, Baltimore, Maryland, USA.
  • Liang Liang
    Department of Computer Science, University of Miami, Coral Gables, FL.
  • Mingyu Zhang
    Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, School of Engineering Medicine, Beihang University, Beijing, China; Key Laboratory of Big Data-Based Precision Medicine, Ministry of Industry and Information Technology, People's Republic of China, Beijing, China.
  • Huifen Liu
    Department of psychiatry, Affiliated Kangning Hospital of Ningbo University, Ningbo, Zhejiang, China.
  • Wenwen Shen
    School of Automation, Huazhong University of Science and Technology, Wuhan 430074, China; Key Laboratory of Image Processing and Intelligent Control of Education Ministry of China, Wuhan 430074, China. Electronic address: wenwenshen@86.com.
  • Wenhua Zhou
    Laboratory of Behavioral Neuroscience, Ningbo Addiction Research and Treatment Center, Ningbo, China.

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