Molecular structure of NRG-1 protein and its impact on adult hypertension and heart failure: A new clinical Indicator diagnosis based on advanced machine learning.

Journal: International journal of biological macromolecules
PMID: 39947530

Abstract

The purpose of this study was to investigate the molecular structure of NRG-1 protein and its mechanism of action in adult hypertensive heart failure. The amino acid sequence of NRG-1 protein was analyzed by bioinformatics method. High-throughput sequencing was used to compare NRG-1 gene expression levels in hypertensive patients and healthy controls. Using advanced machine learning algorithms, large amounts of clinical data are analyzed to identify biomarkers associated with heart failure. Specific mutation sites in the molecular structure of NRG-1 protein were found to be significantly correlated with the occurrence of adult hypertensive heart failure. Through training and validation of machine learning models, we successfully identified a set of biomarkers strongly associated with heart failure, including a specific fragment of the NRG-1 protein.

Authors

  • Qiyuan Bai
    The First Clinical Medical College of Lanzhou University, 730000 Lanzhou, Gansu, China.
  • Hao Chen
    The First School of Medicine, Wenzhou Medical University, Wenzhou, China.
  • Hongxu Liu
  • Xuhua Li
    Key Laboratory of Tropical Translational Medicine of Ministry of Education, College of Biomedical Information and Engineering, Hainan Medical University, Haikou, China.
  • Yang Chen
    Orthopedics Department of the First Affiliated Hospital of Tsinghua University, Beijing, China.
  • Dan Guo
    Khoury College of Computer Sciences, Northeastern University, Boston, MA 02115, USA.
  • Bing Song
    ImmunityBio, 9920 Jefferson Blvd., Culver City, CA, 90232, USA.
  • Cuntao Yu
    The First Clinical Medical College of Lanzhou University, 730000 Lanzhou, Gansu, China; Department of Cardiovascular Surgery, First Hospital of Lanzhou University, 730013 Lanzhou, Gansu, China; Department of Cardiovascular Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, 100006 Beijing, China. Electronic address: ldyy_yuct@lzu.edu.cn.

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