Development and Validation of a Novel Model to Discriminate Idiosyncratic Drug-Induced Liver Injury and Autoimmune Hepatitis.

Journal: Liver international : official journal of the International Association for the Study of the Liver
PMID:

Abstract

BACKGROUND AND AIM: Discriminating between idiosyncratic drug-induced liver injury (DILI) and autoimmune hepatitis (AIH) is critical yet challenging. We aim to develop and validate a machine learning (ML)-based model to aid in this differentiation.

Authors

  • Yu Wang
    Clinical and Technical Support, Philips Healthcare, Shanghai, China.
  • Xuhui Lin
    The Bartlett School of Sustainable Construction, Faculty of the Built Environment, University College London, London, UK.
  • Ying Sun
    CFAR and I2R, Agency for Science, Technology and Research, Singapore.
  • Jimin Liu
    Department of Pathology, Mount Sinai Hospital, Toronto, Ontario, Canada.
  • Jia Li
    Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan Tsuihang New District, Guangdong, 528400, PR China; School of Pharmacy, Zunyi Medical University, Zunyi, 563000, PR China; National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, PR China.
  • Qiuju Tian
    Department of Hepatology, The Affiliated Hospital of Qingdao University, Qingdao, China.
  • Feng Guo
  • Xiaoli Hu
    Department of Radiology, First Affiliated Hospital of Hunan University of Chinese Medicine, 410000 Changsha, China.
  • Liang Wang
    Information Department, Dazhou Central Hospital, Dazhou 635000, China.
  • Pingying Li
    Department of Gastroenterology, Qinghai People's Hospital, Xining, Qinghai, China.
  • Jingshou Chen
    Department of Infectious Diseases, The First Affiliated Hospital of Xiamen University, Xiamen, China.
  • Yan Wang
    College of Animal Science and Technology, Beijing University of Agriculture, Beijing, China.
  • Zikun Ma
    Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  • Jidong Jia
    Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  • Jing Zhang
    MOEMIL Laboratory, School of Optoelectronic Information, University of Electronic Science and Technology of China, Chengdu, China.
  • Zhengsheng Zou
    Department of Hepatology, The Fifth Medical Center of PLA General Hospital, Beijing, China.
  • Xinyan Zhao
    School of Information, University of Michigan, Ann Arbor, Michigan, USA.