The reality of modeling irritable bowel syndrome: progress and challenges.

Journal: Expert opinion on drug discovery
PMID: 40162721

Abstract

INTRODUCTION: Irritable bowel syndrome (IBS) is a common gastrointestinal disorder that is often therapeutically challenging. While research has advanced our understanding of IBS pathophysiology, developing precise models to predict drug response and treatment outcomes remains a significant hurdle.

Authors

  • Maryam S Fakhri Bafghi
    Department of Internal Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
  • Niloofar Khoshnam Rad
    Thoracic Research Center, Imam Khomeini Hospital Complex, Tehran, Iran.
  • Ghazal Roostaei
    Thoracic Research Center, Imam Khomeini Hospital Complex, Tehran, Iran.
  • Shekoufeh Nikfar
    Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
  • Mohammad Abdollahi
    Toxicology and Diseases Group (TDG), Pharmaceutical Sciences Research Center (PSRC), The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran.

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