Development and validation of an interpretable machine learning model for predicting the risk of hepatocellular carcinoma in patients with chronic hepatitis B: a case-control study.

Journal: BMC gastroenterology
PMID:

Abstract

BACKGROUND: The aim of this study was to develop and internally validate an interpretable machine learning (ML) model for predicting the risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B (CHB) infection.

Authors

  • Linghong Wu
    Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning, Guangxi, 530021, China.
  • Zengjing Liu
    Information and Management College of Guangxi Medical University, Nanning, Guangxi, 530021, China.
  • Hongyuan Huang
    Department of Urology, Jinjiang Municipal Hospital, Quanzhou, Fujian Province, 362200, China.
  • Dongmei Pan
    Medical Records Data Center, The Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, Guangxi, 545000, China.
  • Cuiping Fu
    Department of Respiratory Medicine, The First Affiliated Hospital of Soochow University, 215006, Suzhou, Jiangsu, China. fucuipingjy@163.com.
  • Yao Lu
    Department of Laboratory Medicine, The First Affiliated Hospital of Ningbo University, Ningbo First Hospital, Ningbo, China.
  • Min Zhou
    Department of Respiratory and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
  • Kaiyong Huang
    Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning, Guangxi, 530021, China.
  • TianRen Huang
    Department of Epidemiology and Biostatistics, School of Public Health, Guangxi Medical University, Nanning, Guangxi, 530021, China. tianrenhuang@sina.com.
  • Li Yang
    Department of Pharmacy, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.