Addressing underestimation and explanation of retinal fundus photo-based cardiovascular disease risk score: Algorithm development and validation.

Journal: Computers in biology and medicine
PMID:

Abstract

OBJECTIVE: To resolve the underestimation problem and investigate the mechanism of the AI model which employed to predict cardiovascular disease (CVD) risk scores from retinal fundus photos.

Authors

  • Zhihong Lin
    Faculty of Engineering, Monash University, Clayton, VIC, 3800, Australia. Electronic address: zhihong.lin@monash.edu.
  • Chi Liu
  • Danli Shi
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
  • Yueye Wang
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060, China.
  • Wenyi Hu
    Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia.
  • Jacqueline Henwood
    Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia.
  • Katerina Kiburg
    Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia.
  • Peter van Wijngaarden
    Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, Melbourne, VIC.
  • Malcolm Clark
    Department of General Practice, University of Melbourne, Melbourne, Australia.
  • Xianwen Shang
    Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia.
  • Xiaotong Han
    From the State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science (J.Z., A.J., X.H., Y.Z., X.Q., X.T., L.L., Y.L.), Guangzhou, China; Guangdong Provincial Clinical Research Center for Ocular Diseases (J.Z., A.J., X.H., Y.Z., X.Q., X.T., L.L., Y.L.), Guangzhou, China.
  • Lei Zhang
    Division of Gastroenterology, Union Hospital, Tongji Medical College Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Mingguang He
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China; Centre for Eye Research Australia; Departments of Ophthalmology and Surgery, University of Melbourne, Melbourne, Australia. Electronic address: mingguang.he@unimelb.edu.au.
  • Zongyuan Ge
    AIM for Health Lab, Faculty of IT, Monash University, Clayton, Victoria, Australia; Monash-Airdoc Research Lab, Faculty of IT, Monash University, Clayton, Victoria, Australia.