BACKGROUND: The potential for generative artificial intelligence (GenAI) to assist with clinical tasks is the subject of ongoing debate within biomedical informatics and related fields.
Understanding how risk factors interact to jointly influence disease risk can provide insights into disease development and improve risk prediction. Here we introduce survivalFM, a machine learning extension to the widely used Cox proportional hazard...
BACKGROUND: Crisis support services offer crucial intervention for individuals in acute distress, providing timely access to trained volunteers whose human connection is key to the effectiveness of these services. However, there are significant dispa...
Plasma proteomics provides a unique opportunity to enhance disease prediction by capturing protein expression patterns linked to diverse pathological processes. Leveraging data from 2,923 proteins measured in 53,030 UK Biobank participants, we develo...
Cerebral palsy (CP) is associated with musculoskeletal complications in children, notably hip migration, which can progress to hip dislocation and joint degeneration. Without regular radiological monitoring, early-stage hip migration can be missed, p...
BACKGROUND: Endoscopic surveillance is the clinical standard for Barrett's oesophagus, but its effectiveness is inconsistent. We have developed a test comprising a pan-oesophageal cell collection device coupled with biomarkers to stratify patients in...
This paper explores the relationship between Artificial Intelligence (AI) integration in the workplace, cultural orientation, and its impact on job autonomy and creative self-efficacy. Our study employs a mixed-method experimental design across 480 i...
Polygenic scores, which estimate an individual's genetic propensity for a disease or trait, have the potential to become part of genomic healthcare. Neural-network based deep-learning has emerged as a method of intense interest to model complex, nonl...
BACKGROUND: Health disparities persist and are influenced by digital transformation. Although digital tools offer opportunities, they can also exacerbate existing inequalities, a problem amplified by the COVID-19 pandemic and the related infodemic. H...
BACKGROUND: Menopausal hormone therapy (MHT) is generally thought to be neuroprotective, yet results have been inconsistent. Here, we present a comprehensive study of MHT use and brain characteristics in females from the UK Biobank.
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