Does the alternating timing of rTMS combined with soft-hand rehabilitation robot affect the recovery of hand function in patients after stroke? A study protocol for a multicentre randomised controlled trial.

Journal: BMJ open
PMID: 40032377

Abstract

INTRODUCTION: Combining repetitive transcranial magnetic stimulation (rTMS) with robotic training could result in more significant improvements in motor function than either treatment alone. The efficacy of this combination may depend on the sequencing of the interventions. However, few studies have explored the possibility of interleaving or alternating between the two treatment modalities within a single session or over a shorter time frame. The objective of this study is to evaluate the efficacy of alternating rTMS and soft-hand rehabilitation robot therapy to enhance upper limb and hand function in patients with ischaemic stroke.

Authors

  • Xinyue Wang
    Department of Otorhinolaryngology-Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, China.
  • Xiaobing Chen
    Department of Rehabilitation Medicine, Zhongda Hospital Southeast University, Nanjing, Jiangsu, China.
  • Kai Leng Catherine Chan
    School of Rehabilitation Medicine, Nanjing Medical University, Nanjing, Jiangsu, China.
  • Xuejing Li
    Department of Rehabilitation Medicine, The Affiliated Huaian Hospital of Xuzhou Medical University, Huai'an, Jiangsu, China.
  • Fei Lu
    College of Information Engineering, Zhejiang University of Technology, Liuhe Rd. 288, Hangzhou 310023, China.
  • Chuan Guo
    Rehabilitation Medicine Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
  • Wenjun Dai
    Rehabilitation Medicine Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
  • Ting Zhou
    Department of Nephrology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
  • Jiang Xu
    Department of Rehabilitation Medicine, The Affiliated Huaian Hospital of Xuzhou Medical University, Huai'an, Jiangsu, China.
  • Qinglun Su
    Rehabilitation Medicine Department, The First People' s Hospital of Lianyugang, Lianyungang, Jiangsu, China.
  • Hongxing Wang
    Department of Rehabilitation Medicine, Zhongda Hospital Southeast University, Nanjing, 210009, China. 101012648@seu.edu.cn.
  • Ying Shen

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