Prediction of Seronegative Hashimoto's thyroiditis using machine learning models based on ultrasound radiomics: a multicenter study.

Journal: BMC immunology
PMID:

Abstract

BACKGROUND: Seronegative Hashimoto's thyroiditis is often underdiagnosed due to the lack of antibody markers. Combining ultrasound radiomics with machine learning offers potential for early detection in patients with normal thyroid function.

Authors

  • Wenjun Wu
    Department of Medical Education and Biomedical Informatics, University of Washington, Seattle, WA.
  • Shengsheng Yao
    Department of Thyroid and Breast Surgery, People's Hospital of China Medical University (Liaoning Provincial People's Hospital), Shenyang, China.
  • Daming Liu
    Department of Ultrasound Medicine, People's Hospital of China Medical University (Liaoning Provincial People's Hospital), Shenyang, China.
  • Yuan Luo
    Department of Preventive Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA.
  • Yihan Sun
    Department of Cardiology, People's Hospital of China Medical University (Liaoning Provincial People's Hospital), Shenyang, China.
  • Ting Ruan
    Key Laboratory of Food Quality and Safety of Guangdong Province, College of Food Science, South China Agricultural University, Guangzhou, 510642, China.
  • Mengyou Liu
    Department of Thyroid Surgery, Lixin County People's Hospital, Haozhou, China.
  • Li Shi
    Department of Integrated Chinese and Western Medicine, Second Xiangya Hospital, Central South University, Changsha 410011, China.
  • Chang Liu
    Key Lab of Cell Differentiation and Apoptosis of Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Mingming Xiao
    Department of Biochemistry and Molecular Biology, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Key Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, Tianjin Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, 300060, China.
  • Qi Zhang
    Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, China.
  • Zhengshuai Liu
    Fengcheng Phoenix Hospital, Dandong, China.
  • Xingai Ju
    Department of General Medicine, People's Hospital of China Medical University (Liaoning Provincial People's Hospital), Shenyang, China.
  • Jiahao Wang
    Unit for Laboratory Animal Medicine, Department of Microbiology and Immunology, Center for Computational Medicine and Bioinformatics, and Comprehensive Cancer Center, University of Michigan Medical School, 1301 MSRB III, 1150 W. Medical Dr, Ann Arbor, MI, 48109, USA.
  • Xiang Fei
    Department of Thyroid and Breast Surgery, People's Hospital of China Medical University (Liaoning Provincial People's Hospital), Shenyang, China.
  • Li Lu
    Department of Ophthalmology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
  • Yang Gao
    State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China.
  • Ying Zhang
    Department of Nephrology, Nanchong Central Hospital Affiliated to North Sichuan Medical College, Nanchong, China.
  • Liying Gong
    Department of Medical Laboratory, People's Hospital of China Medical University (Liaoning Provincial People's Hospital), Shenyang, China.
  • Xuanyu Chen
    School of Mathematics, Sun Yat-sen University, Guangzhou, China.
  • Wanli Zheng
    Jinzhou Medical University, Jinzhou, China.
  • Xiali Niu
    Department of General Medicine, People's Hospital of China Medical University (Liaoning Provincial People's Hospital), Shenyang, China.
  • Xiao Yang
    Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
  • Huimei Cao
    Jinzhou Medical College Linghai Dalinghe Hospital, Jinzhou, China.
  • Shijie Chang
    Department of Biomedical Engineering, China Medical University, Shenyang, 110122.
  • Jianchun Cui
    Department of Thyroid and Breast Surgery, People's Hospital of China Medical University (Liaoning Provincial People's Hospital), Shenyang, China. cjc7162003@aliyun.com.
  • Zuoxin Ma
    Department of Medical Laboratory, People's Hospital of China Medical University (Liaoning Provincial People's Hospital), Shenyang, China. mzx533@163.com.