AI-Assisted Hypothesis Generation to Address Challenges in Cardiotoxicity Research: Simulation Study Using ChatGPT With GPT-4o.

Journal: Journal of medical Internet research
PMID:

Abstract

BACKGROUND: Cardiotoxicity is a major concern in heart disease research because it can lead to severe cardiac damage, including heart failure and arrhythmias.

Authors

  • Yilan Li
    Center of Water Resources and Environment, School of Civil Engineering, Sun Yat-Sen University, Guangzhou, 510275, China.
  • Tianshu Gu
    School of Mechanic Engineering, Northeast Electric Power University, Jilin, 132012, China.
  • Chengyuan Yang
    Department of Orthopedic Surgery and BME-Campbell Clinic, University of Tennessee Health Science Centre, Memphis, TN, 38163, USA. Electronic address: cyang31@uthsc.edu.
  • Minghui Li
    MOE Key Laboratory of Geriatric Diseases and Immunology, School of Biology and Basic Medical Sciences, Suzhou Medical College of Soochow University, Suzhou, Jiangsu Province 215123, China.
  • Congyi Wang
    Diabetes Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Doha, Qatar.
  • Lan Yao
    Key Laboratory of Molecular Biophysics of Ministry of Education, Hubei Bioinformatics and Molecular Imaging Key Laboratory, Center for Artificial Intelligence Biology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China.
  • Weikuan Gu
    Department of Orthopaedic Surgery and BME-Campbell Clinic, University of Tennessee Health Science Center, Memphis, TN, USA; Lt. Col. Luke Weathers, Jr. VA Medical Center, 116 N Pauline St, Memphis, TN 38105, USA; Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA. Electronic address: wgu@uthsc.edu.
  • Dianjun Sun
    Key Laboratory of Etiologic Epidemiology, Education Bureau of Heilongjiang Province & Ministry of Health 23618104, 157 Baojian Road, Harbin, Heilongjiang 150081, China; Centre for Endemic Disease Control, Chinese Centre for Disease Control and Prevention, Harbin Medical University, Education Bureau of Heilongjiang Province &∼ Ministry of Health 23618104, 157 Baojian Road, Harbin, Heilongjiang 150081, China. Electronic address: hrbmusdj@163.com.