Optimal Vasopressin Initiation in Septic Shock: The OVISS Reinforcement Learning Study.

Journal: JAMA

Published Date: May 20, 2025

Abstract

IMPORTANCE: Norepinephrine is the first-line vasopressor for patients with septic shock. When and whether a second agent, such as vasopressin, should be added is unknown.

Authors

Alexandre Kalimouttou

Inserm UMR 1153, Centre for Research in Epidemiology and Statistics (CRESS), ECSTRRA Team, Université Paris Cité and Université Sorbonne Paris Nord, Paris, France.
Jason N Kennedy

Department of Critical Care Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
Jean Feng

Department of Biostatistics, University of Washington, Seattle, WA.
Harvineet Singh

Department of Epidemiology & Biostatistics, University of California, San Francisco.
Suchi Saria

Department of Computer Science, Johns Hopkins University, Baltimore, MD.
Derek C Angus

Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Christopher W Seymour

Department of Critical Care Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
Romain Pirracchio

Keywords

Aged Clinical Decision-Making Critical Illness Datasets as Topic Electronic Health Records Female Hospital Mortality Humans Male Middle Aged Norepinephrine Observational Studies as Topic Organ Dysfunction Scores Practice Guidelines as Topic Reinforcement Machine Learning Shock, Septic Vasoconstrictor Agents Vasopressins

External Resources

View on PubMed Access via DOI PubMed (40098600)

Optimal Vasopressin Initiation in Septic Shock: The OVISS Reinforcement Learning Study.

Abstract

Authors

Keywords

External Resources

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