AIMC Topic: Norepinephrine
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Brainstem noradrenergic modulation of the kisspeptin neuron GnRH pulse generator in mice.
Nature communications
Jul 1, 2025
Brainstem noradrenaline (NA) neurons modulate the activity of many neural networks including those responsible for the control of fertility. Using brain slice electrophysiology, we demonstrate that the arcuate nucleus kisspeptin (ARN) neurons, recent...
Analysis of the heterogeneous treatment effect of vasoactive drug dosage and time on hospital mortality across different sepsis phenotypes: a retrospective cohort study.
European journal of medical research
May 24, 2025
BACKGROUND: The heterogeneity of sepsis poses challenges for the individualized treatment of vasoactive drugs.
Application of causal forests to randomised controlled trial data to identify heterogeneous treatment effects: a case study.
BMC medical research methodology
Feb 22, 2025
BACKGROUND: Classical approaches to subgroup analysis in randomised controlled trials (RCTs) to identify heterogeneous treatment effects (HTEs) involve testing the interaction between each pre-specified possible treatment effect modifier and the trea...
Fillable Magnetic Microrobots for Drug Delivery to Cardiac Tissues In Vitro.
Advanced healthcare materials
May 29, 2024
Many cardiac diseases, such as arrhythmia or cardiogenic shock, cause irregular beating patterns that must be regulated to prevent disease progression toward heart failure. Treatments can include invasive surgery or high systemic drug dosages, which ...
Resolution of tonic concentrations of highly similar neurotransmitters using voltammetry and deep learning.
Molecular psychiatry
Apr 25, 2024
With advances in our understanding regarding the neurochemical underpinnings of neurological and psychiatric diseases, there is an increased demand for advanced computational methods for neurochemical analysis. Despite having a variety of techniques ...
Automatic segmentation of the interscapular brown adipose tissue in rats based on deep learning using the dynamic magnetic resonance fat fraction images.
Magma (New York, N.Y.)
Nov 29, 2023
OBJECTIVE: The study aims to propose an accurate labelling method of interscapular BAT (iBAT) in rats using dynamic MR fat fraction (FF) images with noradrenaline (NE) stimulation and then develop an automatic iBAT segmentation method using a U-Net m...
Antibiotics, Sedatives, and Catecholamines Further Compromise Sepsis-Induced Immune Suppression in Peripheral Blood Mononuclear Cells.
Critical care medicine
Nov 20, 2023
OBJECTIVES: We hypothesized that the immunosuppressive effects associated with antibiotics, sedatives, and catecholamines amplify sepsis-associated immune suppression through mitochondrial dysfunction, and there is a cumulative effect when used in co...
Time-resolved neurotransmitter detection in mouse brain tissue using an artificial intelligence-nanogap.
Scientific reports
Jul 9, 2020
The analysis of neurotransmitters in the brain helps to understand brain functions and diagnose Parkinson's disease. Pharmacological inhibition experiments, electrophysiological measurement of action potentials, and mass analysers have been applied f...
Neurotransmitter networks in mouse prefrontal cortex are reconfigured by isoflurane anesthesia.
Journal of neurophysiology
Apr 29, 2020
This study quantified eight small-molecule neurotransmitters collected simultaneously from prefrontal cortex of C57BL/6J mice ( = 23) during wakefulness and during isoflurane anesthesia (1.3%). Using isoflurane anesthesia as an independent variable e...
Identification of Catecholamine Neurotransmitters Using a Fluorescent Electronic Tongue.
ACS chemical neuroscience
Dec 19, 2019
Catecholamine neurotransmitters, specifically, dopamine (DA), epinephrine (EP), and norepinephrine (NE), are known as substantial indicators of various neurological diseases. Developing rapid detection methods capable of simultaneously screening thei...
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