NDDRF 2.0: An update and expansion of risk factor knowledge base for personalized prevention of neurodegenerative diseases.

Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association
Published Date: May 1, 2025

Abstract

INTRODUCTION: Neurodegenerative diseases (NDDs) are chronic diseases caused by brain neuron degeneration, requiring systematic integration of risk factors to address their heterogeneity. Established in 2021, Knowledgebase of Risk Factors for Neurodegenerative Diseases (NDDRF) was the first knowledge base to consolidate NDD risk factors. NDDRF 2.0 expands focus to modifiable lifestyle-related factors, enhancing utility for NDD prevention.

Authors

  • Cheng Bi
    Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610212, Sichuan, China; Center for Systems Biology, Soochow University, Suzhou 215006, Jiangsu, China.
  • Xin Zheng
    Department of Clinical Laboratory, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address: dearjanna@126.com.
  • Yuxin Zhang
    State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology , Sichuan University , Chengdu 610041 , People's Republic of China.
  • Shengrong Zhou
    Center for Systems Biology, Soochow University, Suzhou 215006, Jiangsu, China.
  • Jie Song
    School of Chemistry, Dalian University of Technology, Dalian 116023, PR China.
  • Huifang Shang
    Department of Neurology, West China Hospital of Sichuan University, Chengdu, China.
  • Bairong Shen
    Institute of Systems Genetics, Department of Critical Care Medicine, Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610000, China.

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