AIMC Topic: Neurodegenerative Diseases
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Advancements in the investigation of the mechanisms underlying cognitive aging.
Biogerontology
Aug 10, 2025
Cognitive aging, a pivotal domain at the intersection of neuroscience and psychology, exhibits a strong association with neurodegenerative disorders; however, its comprehensive underlying mechanisms remain incompletely elucidated. This review aims to...
Targeting neurodegeneration: three machine learning methods for G9a inhibitors discovery using PubChem and scikit-learn.
Journal of computer-aided molecular design
Aug 6, 2025
In light of the increasing interest in G9a's role in neuroscience, three machine learning (ML) models, that are time efficient and cost effective, were developed to support researchers in this area. The models are based on data provided by PubChem an...
Structural modification strategies for ferritin nanoparticles and their applications in biomedicine: a narrative review.
Nanoscale
Jul 31, 2025
Ferritin is an iron-storage protein that naturally self-assembles into a hollow spherical particle consisting of 24 identical subunits, and it serves a central role in iron metabolism. Ferritin's favorable drug-loading capacity, biocompatibility, int...
Self-driving microscopy detects the onset of protein aggregation and enables intelligent Brillouin imaging.
Nature communications
Jul 24, 2025
The process of protein aggregation, central to neurodegenerative diseases like Huntington's, is challenging to study due to its unpredictable nature and relatively rapid kinetics. Understanding its biomechanics is crucial for unraveling its role in d...
Public hesitancy for AI-based detection of neurodegenerative diseases in France.
Scientific reports
Jul 23, 2025
Recent advances in artificial intelligence (AI) have made it possible to detect neurodegenerative diseases (NDDs) earlier, potentially improving patient outcomes. However, AI-based detection tools remain underutilized. We studied individual valuation...
Biomarkers and therapeutic strategies targeting microglia in neurodegenerative diseases: current status and future directions.
Molecular neurodegeneration
Jul 10, 2025
Recent advances in our understanding of non-cell-autonomous mechanisms in neurodegenerative diseases (NDDs) have highlighted microglial dysfunction as a core driver of disease progression. Conditions such as Alzheimer's disease (AD), amyotrophic late...
Integrative machine learning and molecular simulation approaches identify GSK3β inhibitors for neurodegenerative disease therapy.
Scientific reports
Jul 1, 2025
Neurodegenerative diseases (NDDs), including Alzheimer's disease (AD) and Parkinson's disease (PD), are a growing global health concern, especially among the elderly, posing significant challenges to well-being and survival. GSK3β, a serine/threonine...
Ultradeep N-glycoproteome atlas of mouse reveals spatiotemporal signatures of brain aging and neurodegenerative diseases.
Nature communications
Jul 1, 2025
The current depth of site-specific N-glycoproteomics is insufficient to fully characterize glycosylation events in biological samples. Herein, we achieve an ultradeep and precision analysis of the N-glycoproteome of mouse tissues by integrating multi...
Regional free-water diffusion is more strongly related to neuroinflammation than neurodegeneration.
Journal of neurology
Jun 25, 2025
INTRODUCTION: Recent research has suggested that neuroinflammation may be important in the pathogenesis of neurodegenerative diseases. Free-water diffusion (FWD) has been proposed as a non-invasive neuroimaging-based biomarker for neuroinflammation.
Uncovering injury-specific proteomic signatures and neurodegenerative risks in single and repetitive traumatic brain injury.
Signal transduction and targeted therapy
Jun 23, 2025
Traumatic brain injury (TBI) is a major public health concern associated with an increased risk of neurodegenerative diseases including Alzheimer's disease (AD), Parkinson's disease (PD), and chronic traumatic encephalopathy, yet the underlying molec...
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