Peak analysis of cell-free RNA finds recurrently protected narrow regions with clinical potential.

Journal: Genome biology
PMID: 40340952

Abstract

BACKGROUND: Cell-free RNAs (cfRNAs) can be detected in biofluids and have emerged as valuable disease biomarkers. Accurate identification of the fragmented cfRNA signals, especially those originating from pathological cells, is crucial for understanding their biological functions and clinical value. However, many challenges still need to be addressed for their application, including developing specific analysis methods and translating cfRNA fragments with biological support into clinical applications.

Authors

  • Pengfei Bao
    MOE Key Laboratory of Bioinformatics, State Key Lab of Green Biomanufacturing, Center for Synthetic and Systems Biology, School of Life Sciences, Tsinghua University, Beijing, 100084, China.
  • Taiwei Wang
    MOE Key Laboratory of Bioinformatics, State Key Lab of Green Biomanufacturing, Center for Synthetic and Systems Biology, School of Life Sciences, Tsinghua University, Beijing, 100084, China.
  • Xiaofan Liu
    1State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, Hubei Province, China; email: daohongjiang@mail.hzau.edu.cn, jiasencheng@mail.hzau.edu.cn.
  • Shaozhen Xing
    MOE Key Laboratory of Bioinformatics, State Key Lab of Green Biomanufacturing, Center for Synthetic and Systems Biology, School of Life Sciences, Tsinghua University, Beijing, 100084, China.
  • Hanjin Ruan
    Department of Oral and Maxillofacial & Head and Neck Oncology, Beijing Stomatological Hospital, Capital Medical University, Beijing, China.
  • Hongli Ma
    MOE Key Laboratory of Bioinformatics, State Key Lab of Green Biomanufacturing, Center for Synthetic and Systems Biology, School of Life Sciences, Tsinghua University, Beijing, 100084, China.
  • Yuhuan Tao
    MOE Key Laboratory of Bioinformatics, State Key Lab of Green Biomanufacturing, Center for Synthetic and Systems Biology, School of Life Sciences, Tsinghua University, Beijing, 100084, China.
  • Qing Zhan
    MOE Key Laboratory of Bioinformatics, State Key Lab of Green Biomanufacturing, Center for Synthetic and Systems Biology, School of Life Sciences, Tsinghua University, Beijing, 100084, China.
  • Efres Belmonte-Reche
    Centre for Genomics and Oncological Research (GENYO), Avenida de La Ilustración 114, Granada, 18016, Spain.
  • Lizheng Qin
    Department of Oral and Maxillofacial & Head and Neck Oncology, Beijing Stomatological Hospital, Capital Medical University, Beijing, China.
  • Zhengxue Han
    Department of Oral and Maxillofacial & Head and Neck Oncology, Beijing Stomatological Hospital, Capital Medical University, Beijing, China.
  • Minghui Mao
    Department of Oral and Maxillofacial & Head and Neck Oncology, Beijing Stomatological Hospital, Capital Medical University, Beijing, China. mmh_hover@163.com.
  • Mengtao Li
    Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China. mengtao.li@cstar.org.cn.
  • Zhi John Lu
    MOE Key Laboratory of Bioinformatics, State Key Lab of Green Biomanufacturing, Center for Synthetic and Systems Biology, School of Life Sciences, Tsinghua University, Beijing, 100084, China. zhilu@tsinghua.edu.cn.

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