Emerging research themes in ferroptosis research for non-small cell lung cancer: a bibliometric and visualized analysis.

Journal: Frontiers in immunology
Published Date: May 16, 2025

Abstract

BACKGROUND: Ferroptosis, an iron-dependent form of regulated cell death, has garnered significant attention as a potential therapeutic target in oncology due to its unique mechanism involving lipid peroxidation and reactive oxygen species accumulation. In non-small cell lung cancer (NSCLC), ferroptosis offers promising strategies to overcome drug resistance and enhance the efficacy of existing therapies. While the literature on ferroptosis in NSCLC has expanded rapidly over the past decade, a comprehensive understanding of its research trends, global collaboration patterns, and emerging hotspots remains lacking.

Authors

  • Wenbo Zhang
    Department of Ophthalmology and Visual Sciences, University of Texas Medical Branch, TX, 77555-0144, USA.
  • Jianwei Gu
    School of Traditional Chinese and Western Medicine, Gansu University of Chinese Medicine, Lanzhou, China.
  • Yong Chen
    Department of Urology, Chongqing University Fuling Hospital, Chongqing, China.
  • Guolu Jiang
    Department of Pulmonary and Critical Care Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
  • Diego Gonzalez-Rivas
    Minimally Invasive Thoracic Surgery Unit (UCTMI), Department of Thoracic Surgery, Coruña University Hospital, Xubias 84, Coruña 15006, Spain; Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, 507, Road Zhengmin, Shanghai 200433, China. Electronic address: diego.gonzalez.rivas@sergas.es.
  • Minjie Ma
    From the Departments of Thoracic Surgery (Y.Z., Y. She, J.D., D.X., C.C.), Radiology (T.W., J.S.), and Pathology (C.W.), Shanghai Pulmonary Hospital, Tongji University School of Medicine, 507 Zhengmin Rd, Shanghai 200433, China; Department of Computer Science and Technology, College of Electronics and Information Engineering, Tongji University, Shanghai, China (S.C., H.Q., Y.W.); Department of Thoracic Surgery, Ningbo No. 2 Hospital, Chinese Academy of Sciences, Zhejiang, China (M.Y.); Department of Thoracic Surgery, The First Hospital of Lanzhou University, Gansu, China (M.M., C.C.); The International Science and Technology Cooperation Base for Development and Application of Key Technologies in Thoracic Surgery, Gansu Province, China (M.M., C.C.); and Department of Thoracic Surgery, Affiliated Hospital of Zunyi Medical College, Zunyi Medical College, Guizhou, China (Y. Song).
  • Chang Chen
    Biomass Energy and Environmental Engineering Research Center, College of Chemical Engineering, Beijing University of Chemical Technology, 505 Zonghe Building A, 15 North 3rd Ring East Road, Beijing, 100029, China. chenchang@mail.buct.edu.cn.

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