AIMC Topic: Carcinoma, Non-Small-Cell Lung

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Open-radiomics: a collection of standardized datasets and a technical protocol for reproducible radiomics machine learning pipelines.

BMC medical imaging Aug 4, 2025
BACKGROUND: As an important branch of machine learning pipelines in medical imaging, radiomics faces two major challenges namely reproducibility and accessibility. In this work, we introduce open-radiomics, a set of radiomics datasets along with a co...
Female Reproducibility of Results Adult Radiomics Humans Machine Learning Glioma Carcinoma, Non-Small-Cell Lung Magnetic Resonance Imaging Survival Analysis Datasets as Topic Brain Neoplasms Male Middle Aged Lung Neoplasms
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Gut microbiota and SCFAs improve the treatment efficacy of chemotherapy and immunotherapy in NSCLC.

NPJ biofilms and microbiomes Jul 28, 2025
The role of gut dysbiosis in shaping immunotherapy responses is well-recognized, yet its effect on the therapeutic efficacy of chemotherapy and immunotherapy combinations remains poorly understood. We analyzed gut microbiota in non-small cell lung ca...
Fatty Acids, Volatile Metagenomics Mice Bacteria Immunotherapy Male Carcinoma, Non-Small-Cell Lung Humans Treatment Outcome Gastrointestinal Microbiome Middle Aged Female RNA, Ribosomal, 16S Fecal Microbiota Transplantation Antineoplastic Agents Aged Dysbiosis Animals Lung Neoplasms
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Machine-learning driven strategies for adapting immunotherapy in metastatic NSCLC.

Nature communications Jul 24, 2025
Immune checkpoint inhibitors (ICIs), either as monotherapy (ICI-Mono) or combined with chemotherapy (ICI-Chemo), improves survival in advanced non-small cell lung cancer (NSCLC). However, prospective guidance for choosing between these options remain...
Humans Machine Learning Female Immune Checkpoint Inhibitors Lung Neoplasms B7-H1 Antigen Immunotherapy Carcinoma, Non-Small-Cell Lung Aged Biomarkers, Tumor Male Middle Aged
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Collaborative assessment of the risk of postoperative progression in early-stage non-small cell lung cancer: a robust federated learning model.

Cancer imaging : the official publication of the International Cancer Imaging Society Jul 18, 2025
BACKGROUND: While the TNM staging system provides valuable insights into the extent of disease, predicting postoperative progression in early-stage non-small cell lung cancer (NSCLC) remains a significant challenge. An effective bioimaging prognostic...
Federated Learning Disease Progression Lung Neoplasms Carcinoma, Non-Small-Cell Lung Neoplasm Staging Humans Prognosis Retrospective Studies Male Middle Aged Risk Assessment Female Aged
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Integrative habitat analysis and multi-instance deep learning for predictive model of PD-1/PD-L1 immunotherapy efficacy in NSCLC patients: a dual-center retrospective study.

BMC medical imaging Jul 17, 2025
BACKGROUND: PD-1/PD-L1 immunotherapy represents the primary treatment for advanced NSCLC patients; however, response rates to this therapy vary among individuals. This dual-center study aimed to integrate habitat radiomics and multi-instance deep lea...
Programmed Cell Death 1 Receptor B7-H1 Antigen Immunotherapy Treatment Outcome Carcinoma, Non-Small-Cell Lung Female Middle Aged Aged Deep Learning Male Humans Immune Checkpoint Inhibitors Lung Neoplasms Retrospective Studies
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Decision level scheme for fusing multiomics and histology slide images using deep neural network for tumor prognosis prediction.

Scientific reports Jul 15, 2025
Molecular biostatistical workflows in oncology often rely on predictive models that use multimodal data. Advances in deep learning and artificial intelligence technologies have enabled the multimodal fusion of large volumes of multimodal data. Here, ...
Prognosis Image Processing, Computer-Assisted Humans Female Lung Neoplasms Neural Networks, Computer Multiomics Breast Neoplasms Carcinoma, Non-Small-Cell Lung Deep Learning
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Non-invasive identification of TKI-resistant NSCLC: a multi-model AI approach for predicting EGFR/TP53 co-mutations.

BMC pulmonary medicine Jul 10, 2025
OBJECTIVES: To investigate the value of multi-model based on preoperative CT scans in predicting EGFR/TP53 co-mutation status.
Male Middle Aged Deep Learning China Mutation Drug Resistance, Neoplasm Tumor Suppressor Protein p53 Lung Neoplasms Carcinoma, Non-Small-Cell Lung ErbB Receptors Tomography, X-Ray Computed Protein Kinase Inhibitors Humans Female Retrospective Studies Aged Adult
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Deep Learning-Based Classification of NSCLC-Derived Extracellular Vesicles Using AFM Nanomechanical Signatures.

Analytical chemistry Jul 8, 2025
Nonsmall cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality, with liquid biopsy emerging as a promising tool for noninvasive diagnostics. Extracellular vesicles (EVs) serve as molecular messengers of the tumor microenvironme...
Mutation Microscopy, Atomic Force Deep Learning Cell Line, Tumor Humans Lung Neoplasms Extracellular Vesicles Carcinoma, Non-Small-Cell Lung
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Metabolic alterations driven by LDHA in CD8 + T cells promote immune evasion and therapy resistance in NSCLC.

Scientific reports Jul 8, 2025
Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related deaths worldwide. Despite advancements in treatment, prognosis for patients with advanced stages remains poor. Metabolic reprogramming in the tumor microenvironment, particularly...
Carcinoma, Non-Small-Cell Lung CD8-Positive T-Lymphocytes Humans Drug Resistance, Neoplasm Immune Evasion Tumor Microenvironment L-Lactate Dehydrogenase Prognosis Tumor Escape Lung Neoplasms Lactate Dehydrogenase 5 Glycolysis Gene Expression Regulation, Neoplastic
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The Impact of Machine Learning Mortality Risk Prediction on Clinician Prognostic Accuracy and Decision Support: A Randomized Vignette Study.

Medical decision making : an international journal of the Society for Medical Decision Making Jul 4, 2025
BackgroundMachine learning (ML) algorithms may improve the prognosis for serious illnesses such as cancer, identifying patients who may benefit from earlier palliative care (PC) or advance care planning (ACP). We evaluated the impact of various prese...
Prognosis Humans Middle Aged Carcinoma, Non-Small-Cell Lung Female Machine Learning Risk Assessment Advance Care Planning Adult Algorithms Surveys and Questionnaires Male Decision Support Techniques Lung Neoplasms
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