Comprehensive molecular analyses of an autoimmune-related gene predictive model and immune infiltrations using machine learning methods in intracranial aneurysma.

Journal: Frontiers in immunology
PMID: 40313967

Abstract

BACKGROUND: Increasing evidence indicates a connection between intracranial aneurysm (intracranial aneurysm, IA) and autoimmune diseases. However, the molecular mechanisms from a genetic perspective remain unclear. This study aims to elucidate the potential roles of autoimmune-related genes (ARGs) in the pathogenesis of IA.

Authors

  • Minxue Zhang
    Department of Neurology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.
  • Lin Zhou
    Guangdong Province Key Laboratory for Biotechnology Drug Candidates, School of Biosciences and Biopharmaceutics, Guangdong Pharmaceutical University Guangzhou 510006 People's Republic of China zhoulin@gdpu.edu.cn +86-20-39352151 +86-20-39352151.
  • Yuying Zhao
    Department of Neurology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.
  • Yanling Wang
    Department of Neurology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.
  • Zhuobo Zhang
    Department of Neurology, The Fourth Affiliated Hospital, Harbin Medical University, Harbin, 150001, Heilongjiang, People's Republic of China. drzhangzuobo@163.com.
  • Zhan Liu
    Department of Neurology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.

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