Identification and validation of prognostic genes associated with T-cell exhaustion and macrophage polarization in breast cancer.

Journal: Frontiers in endocrinology
Published Date: May 27, 2025

Abstract

BACKGROUND: The most frequent malignant tumor in women is breast cancer (BRCA). It has been discovered that T-cell exhaustion and macrophages play significant roles in BRCA. It was necessary to explore prognostic genes associated with T-cell exhaustion and macrophage polarization in BRCA.

Authors

  • Fengqiang Cui
    Department of Thyroid, Breast and Vascular Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, China.
  • Changjiao Yan
    Department of Thyroid, Breast and Vascular Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, China.
  • Jiang Wu
    College of Energy and Mechanical Engineering, Shanghai University of Electric Power, Shanghai 200090, China. Electronic address: wjcfd2002@163.com.
  • Yuqing Yang
    State Key Laboratory of Networking and Switching Technology, Beijing University of Posts and Telecommunications, Beijing, China.
  • Jixin Yang
    School of Mechanical Engineering & Automation, Dalian Polytechnic University, Qinggongyuan 1, Ganjingzi District, Dalian 116034, PR China; National Engineering Research Center of Seafood, Dalian Polytechnic University, Qinggongyuan 1, Ganjingzi District, Dalian 116034, PR China; Engineering Research Center of Seafood of Ministry of Education of China, Dalian 116034, PR China; Collaborative Innovation Center of Seafood Deep Processing, Dalian 116034, PR China.
  • Jialing Luo
    Department of Thyroid, Breast and Vascular Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, China.
  • Nanlin Li
    Department of Thyroid, Breast and Vascular Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, China.

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