Applying exposure-response analysis to enhance Mycophenolate Mofetil dosing precision in pediatric patients with immune-mediated renal diseases by machine learning models.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
Published Date: May 28, 2025

Abstract

BACKGROUND: Mycophenolate mofetil (MMF), a cornerstone immunosuppressant for lupus nephritis, is increasingly used off-label in pediatric immune-mediated renal diseases. The aims of this study were to develop and validate pharmacokinetic models for mycophenolic acid (MPA), the active metabolite of MMF, to optimize dosing strategies in Chinese pediatric patients with immune-mediated renal diseases guided by exposure-response analysis.

Authors

  • Lu-Yao Han
    School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, PR China.
  • Xiang Chen
    Yangtze Delta Region Institute (Huzhou), University of Electronic Science and Technology of China, Huzhou, Zhejiang, China.
  • Tian-Shuo Liu
    National Key Laboratory for Novel Software Technology, Nanjing University, Nanjing 210023, PR China.
  • Zhi-Long Zhang
    National Key Laboratory for Novel Software Technology, Nanjing University, Nanjing 210023, PR China.
  • Feng Chen
    Department of Integrated Care Management Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
  • De-Chuan Zhan
    National Key Laboratory for Novel Software Technology, Nanjing University, Nanjing 210023, PR China. Electronic address: zhandc@nju.edu.cn.
  • Yang Yu
    Division of Cardiology, the Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Guo Yu
    School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, PR China. Electronic address: guoyu@cpu.edu.cn.

Keywords

External Resources

Popular Topics
Recent Journals