AIMC Topic: Mycophenolic Acid
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Applying exposure-response analysis to enhance Mycophenolate Mofetil dosing precision in pediatric patients with immune-mediated renal diseases by machine learning models.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
May 28, 2025
BACKGROUND: Mycophenolate mofetil (MMF), a cornerstone immunosuppressant for lupus nephritis, is increasingly used off-label in pediatric immune-mediated renal diseases. The aims of this study were to develop and validate pharmacokinetic models for m...
Multi-stain deep learning prediction model of treatment response in lupus nephritis based on renal histopathology.
Kidney international
Dec 27, 2024
The response of the kidney after induction treatment is one of the determinants of prognosis in lupus nephritis, but effective predictive tools are lacking. Here, we sought to apply deep learning approaches on kidney biopsies for treatment response p...
Mycophenolic Acid Exposure Prediction Using Machine Learning.
Clinical pharmacology and therapeutics
Apr 6, 2021
Therapeutic drug monitoring of mycophenolic acid (MPA) based on area under the curve (AUC) is well-established and machine learning (ML) approaches could help to estimate AUC. The aim of this work is to estimate the AUC of MPA in organ transplant pat...
Machine Learning Modeling for Ultrasonication-Mediated Fermentation of Penicillium brevicompactum to Enhance the Release of Mycophenolic Acid.
Ultrasound in medicine & biology
Dec 14, 2020
Described here is the modeling used to improve the mycophenolic acid (MPA) titer from Penicillium brevicompactum using central composite design and a comparatively newer, data-centric approach method k-nearest-neighbor algorithm. The two models for e...
Estimation of Mycophenolic Acid Exposure in Chinese Renal Transplant Patients by a Joint Deep Learning Model.
Therapeutic drug monitoring
Dec 1, 2022
BACKGROUND: To predict mycophenolic acid (MPA) exposure in renal transplant recipients using a deep learning model based on a convolutional neural network with bilateral long short-term memory and attention methods.
Therapeutic monitoring of mycophenolic acid in renal transplanted patients by a validated HPLC method.
Folia medica
Oct 31, 2021
INTRODUCTION: Mycophenolate mofetil and its active metabolite mycophenolic acid are routinely used as immunosuppressant drugs in solid organ transplantation in a fixed daily dose regimen in association with cyclosporine, tacrolimus and steroids. Ther...
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