The impact of aging on achilles tendon ossification in mice.

Journal: BMC musculoskeletal disorders
Published Date: May 28, 2025

Abstract

BACKGROUND: Heterotopic ossification is a frequent complication of soft tissue injuries, particularly in tendons. Although ossification in tendon tissue has been reported in a range of aging and disease models, the underlying biomarkers and mechanisms remain unknown. And the characterisation and sensitivity of previous diagnostic biomarkers for tendon ectopic ossification do not meet the demands of clinical use. The aim of this study was to characterise the effects of aging on ossification in the mouse Achilles tendon and to identify characteristic genes and therapeutic targets for tendon ossification in mice by using a machine learning approach.

Authors

  • Hanhua Cai
    Department of Orthopedics, Affiliated Hospital of Putian University, Putian, 351100, Fujian, China.
  • Yujian Lan
    School of Integrated Traditional Chinese and Western Medicine, Southwest Medical University, Luzhou, Sichuan 646000, China; Department of Orthopaedics, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan 646000, China.
  • Huan Liu
    Department of Chemical and Biochemical Engineering, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, Fujian, China.
  • Qi Hao
    Department of Radiology, Peking University people' hospital, No.11 Xizhimen South Street, Xicheng District, Beijing, 100044, P. R. China (F.Z., P.Y., Y.W., W.H., Q.H., N.H.).

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