Molecular mechanisms of deer antler in promoting osteogenic differentiation of human mesenchymal stem cells via JUN modulation.

Journal: Frontiers in immunology
Published Date:

Abstract

BACKGROUND: Traditional Chinese medicine and food deer antler has been extensively used in bone regeneration, but its molecular mechanisms remain poorly understood. Preliminary investigations suggest deer antler contains bioactive compounds that influence osteogenic differentiation and immune microenvironments.

Authors

  • Chengcheng Yu
    Second Affiliated Hospital of Zhejiang University, Hangzhou, China.
  • Yinan Wu
    Hangzhou Institute of Medicine (HIM), Zhejiang Cancer Hospital, Chinese Academy of Sciences, Hangzhou, China.
  • Hanxu Huang
    Department of Orthopedics, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
  • Xiumao Li
    Department of Orthopedics, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
  • Jingkai Wang
    Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, China.
  • Chao Liu
    Anti-Drug Technology Center of Guangdong Province, National Anti-Drug Laboratory Guangdong Regional Center, Guangzhou 510230, China.
  • Yuanqing Shen
    Rehabilitation Department, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
  • Donghua Huang
    Beijing DualPi Intelligent Security Technology Co. Ltd., Beijing 100088, China.
  • Ruofu Tang
    Department of Orthopedics, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
  • Zhan Wang
    Interdisciplinary Research Center of Smart Sensor, Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi 710071, China.
  • Lifeng Jiang
    Department of Orthopedics, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
  • Fangcai Li
    Department of Orthopedics, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.