Neurodegeneration Promotes Tumorigenesis in Colorectal Cancer: Insights From Single-Cell and Spatial Multiomics.

Journal: JCO precision oncology
Published Date: Jun 6, 2025

Abstract

PURPOSE: Colorectal cancer (CRC) ranks third in global incidence and second in mortality, with rates increasing among younger populations. The enteric nervous system (ENS) is crucial for gastrointestinal function, and its dysfunction is associated with the progression of CRC. Neurodegeneration may disrupt ENS function and facilitate tumor growth although the mechanisms remain unclear.

Authors

  • Shaocong Mo
    Department of Digestive Diseases, Huashan Hospital, Fudan University, Shanghai, 200040, China. msc245@foxmail.com.
  • Bochen Pan
    Department of Digestive Diseases, The First People's Hospital of Wenling, Wenzhou Medical University, Zhejiang, China.
  • Liming Qin
    School of Clinical Medicine, Youjiang Medical University for Nationalities, Baise, China.
  • Sheng Wang
    Intensive Care Medical Center, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, People's Republic of China.
  • Yulin Wang
    Department of Automation, Tsinghua University, Beijing, China.
  • Midie Xu
    Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China.
  • Fan Xia
  • Wenchao Gu
    Department of Diagnostic and Interventional Radiology, University of Tsukuba, Ibaraki, Japan.

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