AIMC Topic: Carcinogenesis
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Neurodegeneration Promotes Tumorigenesis in Colorectal Cancer: Insights From Single-Cell and Spatial Multiomics.
JCO precision oncology
Jun 6, 2025
PURPOSE: Colorectal cancer (CRC) ranks third in global incidence and second in mortality, with rates increasing among younger populations. The enteric nervous system (ENS) is crucial for gastrointestinal function, and its dysfunction is associated wi...
Unraveling senescence in cancer: mechanistic complexities and therapeutic opportunities.
Molecular biology reports
May 30, 2025
Senescence is a pivotal cellular process, which also plays a major role in development, immune regulation, tissue repair, and aging, triggered by stressors such as telomere shortening, oncogene activation, and DNA damage. Characterized by distinct mo...
Comprehensive analysis of scRNA-seq and bulk RNA-seq data via machine learning and bioinformatics reveals the role of lysine metabolism-related genes in gastric carcinogenesis.
BMC cancer
Apr 9, 2025
BACKGROUND: Gastric cancer (GC) is a highly aggressive and heterogeneous cancer with extremely complex biological characteristics. Lysine and its metabolism are closely related to human cancer, but little is known about how lysine metabolism-related ...
Single-Cell Analysis
RNA-Seq
Gene Regulatory Networks
Stomach Neoplasms
Biomarkers, Tumor
Cell Line, Tumor
Gene Expression Regulation, Neoplastic
Nomograms
Cell Proliferation
Single-Cell Gene Expression Analysis
Computational Biology
Sequence Analysis, RNA
Humans
Machine Learning
Prognosis
Carcinogenesis
Vimentin
Lysine
Mathematical and numerical tumour development modelling for personalised treatment planning.
Biomechanics and modeling in mechanobiology
Apr 8, 2025
This paper presents a mathematical and numerical framework for modelling and parametrising tumour evolution dynamics to enhance computer-aided diagnosis and personalised treatment. The model comprises six differential equations describing cancer cell...
Deep learning prioritizes cancer mutations that alter protein nucleocytoplasmic shuttling to drive tumorigenesis.
Nature communications
Mar 14, 2025
Genetic variants can affect protein function by driving aberrant subcellular localization. However, comprehensive analysis of how mutations promote tumor progression by influencing nuclear localization is currently lacking. Here, we systematically ch...
Radiogenomics and machine learning predict oncogenic signaling pathways in glioblastoma.
Journal of translational medicine
Jan 27, 2025
BACKGROUND: Glioblastoma (GBM) is a highly aggressive brain tumor associated with a poor patient prognosis. The survival rate remains low despite standard therapies, highlighting the urgent need for novel treatment strategies. Advanced imaging techni...
Cross-disease transcriptomic analysis reveals DOK3 and PAPOLA as therapeutic targets for neuroinflammatory and tumorigenic processes.
Frontiers in immunology
Dec 12, 2024
OBJECTIVE: Subarachnoid hemorrhage (SAH) and tumorigenesis share numerous biological complexities; nevertheless, the specific gene expression profiles and underlying mechanisms remain poorly understood. This study aims to identify differentially expr...
Machine learning-based discovery of UPP1 as a key oncogene in tumorigenesis and immune escape in gliomas.
Frontiers in immunology
Sep 24, 2024
INTRODUCTION: Gliomas are the most common and aggressive type of primary brain tumor, with a poor prognosis despite current treatment approaches. Understanding the molecular mechanisms underlying glioma development and progression is critical for imp...
Genome composition-based deep learning predicts oncogenic potential of HPVs.
Frontiers in cellular and infection microbiology
Jul 22, 2024
Human papillomaviruses (HPVs) account for more than 30% of cancer cases, with definite identification of the oncogenic role of viral and genes. However, the identification of high-risk HPV genotypes has largely relied on lagged biological explorati...
Early detection of lung cancer using artificial intelligence-enhanced optical nanosensing of chromatin alterations in field carcinogenesis.
Scientific reports
Aug 22, 2023
Supranucleosomal chromatin structure, including chromatin domain conformation, is involved in the regulation of gene expression and its dysregulation has been associated with carcinogenesis. Prior studies have shown that cells in the buccal mucosa ca...
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