Detection of β-Thalassemia trait from a heterogeneous population with red cell indices and parameters.

Journal: Computers in biology and medicine
Published Date: Apr 26, 2025

Abstract

BACKGROUND: India is home to about 42 million people with β-thalassemia trait (βTT) necessitating screening of βTT to stop spread of the disease. Over the years, researchers developed discrimination formulae based on red blood cell (RBC) parameters to screen β-thalassemia trait from iron deficiency anemia (IDA). However, the screening programs often encounter normal subjects (NSs) with other hemoglobinopathy variants. Because the outcome of existing formulas is binary, they often club normal subjects (NS) or variants such as Hemoglobin E (HbE) traits with either βTT or IDA. Therefore, it is necessary to segregate βTT, IDA, HbE, and NS in mixed population data for rational screening.

Authors

  • Subrata Saha
    Columbia University Irving Medical Center, Columbia University, NY, USA.
  • Prashant Sharma
    Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India.
  • Atul Kumar Jain
    Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India.
  • Bapi Dutta
    Department of Computer Science, University of Jaén, 23071 Jaén, Spain.
  • Luis Martínez
    Department of Computer Science, University of Jaén, 23071 Jaén, Spain.
  • Sarkaft Saleh
    Department of Materials and Production, Aalborg University, DK 9220 Aalborg, Denmark.
  • Tuphan Kanti Dolai
    Department of Hematology, Nil Ratan Sircar Medical College and Hospital, Kolkata, West Bengal, 700014, India.
  • Anilava Kaviraj
    Department of Zoology, University of Kalyani, Kalyani 741235, India.
  • Tanmay Sanyal
    Department of Zoology, Krishnagar Govt. College, Krishnagar, Nadia, West Bengal 741101, India.
  • Izabela Nielsen
    Department of Materials and Production, Aalborg University, DK 9220 Aalborg, Denmark.
  • Reena Das
    Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India. Electronic address: reenadaspgi@gmail.com.

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