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beta-Thalassemia

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Evaluation of the Association of Transferrin Receptor Type 2 Gene Mutation (Y250X) with Iron Overload in Major β- Thalassemia.

Archives of Razi Institute 35355750
Thalassemia is an inherited blood disorder in which the body produces defective hemoglobin. One of the important processes to reduce the complication of major β-thalassemia is blood transfusion that leads to elevated ferritin levels in the blood. Man...
beta-Thalassemia Humans Iron Overload Mutation Receptors, Transferrin Thalassemia
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Profiling of 35 Cases of Hb S/Hb E (: c.20A>T/: c.79G>a), Disease and Association with α-Thalassemia and β-Globin Gene Cluster Haplotypes from Odisha, India.

Hemoglobin 35243949
Hb S/Hb E (: c.20A>T/: c.79G>A) is an uncommon variant of sickle cell disease resulting from coinheritance of Hb S and Hb E. Clinico-hematological and biochemical parameters of 35 cases of Hb S/Hb E disease were studied and compared with 70 matched c...
alpha-Thalassemia Anemia, Sickle Cell beta-Globins beta-Thalassemia Haplotypes Humans Multigene Family
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Prediction of K562 Cells Functional Inhibitors Based on Machine Learning Approaches.

Current pharmaceutical design 31696803
BACKGROUND: β thalassemia is a common monogenic genetic disease that is very harmful to human health. The disease arises is due to the deletion of or defects in β-globin, which reduces synthesis of the β-globin chain, resulting in a relatively excess...
Algorithms Bayes Theorem beta-Globins beta-Thalassemia Humans K562 Cells Machine Learning Support Vector Machine
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ThalPred: a web-based prediction tool for discriminating thalassemia trait and iron deficiency anemia.

BMC medical informatics and decision making 31699079
BACKGROUND: The hypochromic microcytic anemia (HMA) commonly found in Thailand are iron deficiency anemia (IDA) and thalassemia trait (TT). Accurate discrimination between IDA and TT is an important issue and better methods are urgently needed. Altho...
Adolescent Adult Anemia, Hypochromic Anemia, Iron-Deficiency beta-Thalassemia Cluster Analysis Decision Trees Diagnosis, Differential Female Humans Internet Machine Learning Male Middle Aged Neural Networks, Computer Predictive Value of Tests Retrospective Studies ROC Curve Thailand Young Adult
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Conformational changes of β-thalassemia major hemoglobin and oxidative status of plasma after in vitro exposure to extremely low-frequency electromagnetic fields: An artificial neural network analysis.

Electromagnetic biology and medicine 33092422
Electromagnetic fields (EMF) can generate reactive oxygen species and induce oxidative modifications. We investigated the effects of extremely low-frequency electromagnetic fields (ELF-EMF) on oxidative status of plasma and erythrocytes in β-thalasse...
beta-Thalassemia Electromagnetic Fields Hemoglobins Humans Neural Networks, Computer Oxidation-Reduction Oxidative Stress Protein Conformation
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An automated liver segmentation in liver iron concentration map using fuzzy c-means clustering combined with anatomical landmark data.

BMC medical imaging 34583631
BACKGROUND: To estimate median liver iron concentration (LIC) calculated from magnetic resonance imaging, excluded vessels of the liver parenchyma region were defined manually. Previous works proposed the automated method for excluding vessels from t...
Adolescent Algorithms beta-Thalassemia Female Fuzzy Logic Humans Image Interpretation, Computer-Assisted Iron Liver Magnetic Resonance Imaging Male Pattern Recognition, Automated Young Adult
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MRI Deep Learning-Based Automatic Segmentation of Interventricular Septum for Black-Blood Myocardial T2* Measurement in Thalassemia.

Journal of magnetic resonance imaging : JMRI 37941460
BACKGROUND: The T2* value of interventricular septum is routinely reported for grading myocardial iron load in thalassemia major, and automatic segmentation of septum could shorten analysis time and reduce interobserver variability.
Adolescent Adult beta-Thalassemia Deep Learning Female Humans Image Processing, Computer-Assisted Iron Overload Magnetic Resonance Imaging Male Middle Aged Myocardium Observer Variation Reproducibility of Results Retrospective Studies Thalassemia Ventricular Septum Young Adult
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Support Vector Machine-Based Formula for Detecting Suspected α Thalassemia Carriers: A Path toward Universal Screening.

International journal of molecular sciences 38928152
The blood counts of α thalassemia carriers (α-thal) are similar to those of β thalassemia carriers, except for Hemoglobin A (Hb A), which is not elevated. The objective of this study was to determine whether mathematical formulas are effective for de...
alpha-Thalassemia beta-Thalassemia Erythrocyte Indices Female Genetic Carrier Screening Heterozygote Humans Male Support Vector Machine
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Convolutional neural networks for automatic MR classification of myocardial iron overload in thalassemia major patients.

European radiology 39658686
OBJECTIVES: To develop a deep-learning model for supervised classification of myocardial iron overload (MIO) from magnitude T2* multi-echo MR images.
Adolescent Adult beta-Thalassemia Child Convolutional Neural Networks Deep Learning Female Humans Image Interpretation, Computer-Assisted Iron Overload Magnetic Resonance Imaging Male Neural Networks, Computer Retrospective Studies Sensitivity and Specificity Young Adult
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A comprehensive case study of deep learning on the detection of alpha thalassemia and beta thalassemia using public and private datasets.

Scientific reports 40246871
This study explores the performance of deep learning models, specifically Convolutional Neural Networks (CNN) and XGBoost, in predicting alpha and beta thalassemia using both public and private datasets. Thalassemia is a genetic disorder that impairs...
alpha-Thalassemia beta-Thalassemia Databases, Factual Deep Learning Humans Neural Networks, Computer
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