Antimicrobial resistance: Linking molecular mechanisms to public health impact.

Journal: SLAS discovery : advancing life sciences R & D
Published Date: Apr 9, 2025

Abstract

BACKGROUND: Antimicrobial resistance (AMR) develops into a worldwide health emergency through genetic and biochemical adaptations which enable microorganisms to resist antimicrobial treatment. β-lactamases (blaNDM, blaKPC) and efflux pumps (MexAB-OprM) working with mobile genetic elements facilitate fast proliferation of multidrug-resistant (MDR) and exttreme drug-resistant (XDR) phenotypes thus creating major concerns for healthcare systems and community health as well as the agricultural sector.

Authors

  • Ghazala Muteeb
    Department of Nursing, College of Applied Medical Science, King Faisal University, Al-Ahsa, Saudi Arabia.
  • Raisa Nazir Ahmed Kazi
    Department of Respiratory Therapy, College of Applied Medical Science, King Faisal, University, Al-Ahsa, Saudi Arabia.
  • Mohammad Aatif
    Department of Public Health, College of Applied Medical Science, King Faisal University, Al-Ahsa, Saudi Arabia.
  • Asim Azhar
    NAP Life Sciences; Metropolitan Region, Maharashtra 401208, India.
  • Mohamed El Oirdi
    Department of Biological Sciences, College of Science, King Faisal University, Al Ahsa, Saudi Arabia; Department of Basic Sciences, Preparatory Year, King Faisal University, Al-Ahsa, Saudi Arabia.
  • Mohd Farhan
    Department of Basic Sciences, Preparatory Year, King Faisal University, Al-Ahsa, Saudi Arabia; Department of Chemistry, College of Science, King Faisal University, Al Ahsa, Saudi Arabia. Electronic address: mfarhan@kfu.edu.sa.

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