Predicting treatment outcome in congenital adrenal hyperplasia using urine steroidomics and machine learning.

Journal: European journal of endocrinology
Published Date:

Abstract

OBJECTIVE: Treatment monitoring of individuals with congenital adrenal hyperplasia (CAH) remains unsatisfactory. Comprehensive 24 h urine steroid profiling provides detailed insight into adrenal steroid pathways. We investigated whether 24 h urine steroid profiling can predict treatment control in children and adolescents with CAH using machine learning (ML).

Authors

  • Ozair Abawi
    Division of Pediatric Endocrinology, Diabetology and Metabolism, Department of Pediatrics, Bern, University Hospital Inselspital, University of Bern, Bern 3010, Switzerland.
  • Grit Sommer
    Division of Pediatric Endocrinology, Diabetology and Metabolism, Department of Pediatrics, Bern, University Hospital Inselspital, University of Bern, Bern 3010, Switzerland.
  • Michael Grössl
    Department of Biomedical Research, University Hospital Inselspital, University of Bern, Bern 3010, Switzerland.
  • Ulrike Halbsguth
    Division of Pediatric Endocrinology, Diabetology and Metabolism, Department of Pediatrics, Bern, University Hospital Inselspital, University of Bern, Bern 3010, Switzerland.
  • Therina du Toit
    Department of Biomedical Research, University Hospital Inselspital, University of Bern, Bern 3010, Switzerland.
  • Sabine E Hannema
    Division of Endocrinology, Department of Pediatrics, Erasmus MC-Sophia Children's Hospital, University Medical Center Rotterdam, Rotterdam 3000 CA, The Netherlands.
  • Christiaan de Bruin
    Division of Endocrinology, Department of Pediatrics, Willem-Alexander Children's Hospital, Leiden University Medical Center, Leiden 2333 ZA, The Netherlands.
  • Evangelia Charmandari
    Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, National and Kapodistrian University of Athens Medical School, 'Aghia Sophia' Children's Hospital, Athens and Division of Endocrinology and Metabolism, Center for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, 11527, Greece.
  • Erica L T van den Akker
    Department of Paediatrics, Division of Endocrinology, Erasmus Medical Centre -Sophia Children's Hospital, Rotterdam, The Netherlands.
  • Alexander B Leichtle
    Laboratory Medicine, Department of Internal Medicine, Cantonal Hospital Baden, Baden 5404, Switzerland.
  • Christa E Flück
    Division of Pediatric Endocrinology, Diabetology and Metabolism, Department of Pediatrics, Bern, University Hospital Inselspital, University of Bern, Bern 3010, Switzerland.